Clinical characteristics for the subset of cytogenetically abnormal patients (n = 1058)
| Characteristics . | MK−, n (%) . | MK+, n (%) . | P . |
|---|---|---|---|
| No. | 739 | 319 | |
| Sex | .99 | ||
| Male | 406 (55) | 176 (55) | |
| Female | 333 (45) | 143 (45) | |
| Type of AML | .07 | ||
| De novo | 602 (82) | 255 (80) | |
| Secondary | 61 (8) | 19 (6) | |
| Therapy related | 68 (9) | 43 (13) | |
| Age, y | .0001 | ||
| Median (range) | 55.5 (16.7-84.5) | 58.3 (19-81.2) | |
| ≤ 60 | 488 (66) | 189 (59) | .03 |
| > 60 | 251 (34) | 130 (41) | |
| WBC, ×109/L | .0006 | ||
| Median (range) | 9.4 (0.5-427) | 5.8 (0.3-533) | |
| No. missing | 18 | 5 | |
| Hemoglobin, g/dL | .0007 | ||
| Median (range) | 9.2 (4.3-20.6) | 8.8 (3.4-14) | |
| No. missing | 21 | 5 | |
| Platelet count, ×109/L | .08 | ||
| Median | 56 (2-933) | 51 (4-916) | |
| No. missing | 20 | 5 | |
| Percentage of PB blasts | .03 | ||
| Median (range) | 31 (0-100) | 25 (0-99) | |
| No. missing | 72 | 25 | |
| Percentage of BM blasts | .0004 | ||
| Median (range) | 78.5 (4-100) | 63 (8-100) | |
| No. missing | 77 | 33 | |
| LDH value, U/L | .31 | ||
| Median (range) | 386.5 (57-6907) | 377.5 (40-5406) | |
| No. missing | 39 | 9 |
| Characteristics . | MK−, n (%) . | MK+, n (%) . | P . |
|---|---|---|---|
| No. | 739 | 319 | |
| Sex | .99 | ||
| Male | 406 (55) | 176 (55) | |
| Female | 333 (45) | 143 (45) | |
| Type of AML | .07 | ||
| De novo | 602 (82) | 255 (80) | |
| Secondary | 61 (8) | 19 (6) | |
| Therapy related | 68 (9) | 43 (13) | |
| Age, y | .0001 | ||
| Median (range) | 55.5 (16.7-84.5) | 58.3 (19-81.2) | |
| ≤ 60 | 488 (66) | 189 (59) | .03 |
| > 60 | 251 (34) | 130 (41) | |
| WBC, ×109/L | .0006 | ||
| Median (range) | 9.4 (0.5-427) | 5.8 (0.3-533) | |
| No. missing | 18 | 5 | |
| Hemoglobin, g/dL | .0007 | ||
| Median (range) | 9.2 (4.3-20.6) | 8.8 (3.4-14) | |
| No. missing | 21 | 5 | |
| Platelet count, ×109/L | .08 | ||
| Median | 56 (2-933) | 51 (4-916) | |
| No. missing | 20 | 5 | |
| Percentage of PB blasts | .03 | ||
| Median (range) | 31 (0-100) | 25 (0-99) | |
| No. missing | 72 | 25 | |
| Percentage of BM blasts | .0004 | ||
| Median (range) | 78.5 (4-100) | 63 (8-100) | |
| No. missing | 77 | 33 | |
| LDH value, U/L | .31 | ||
| Median (range) | 386.5 (57-6907) | 377.5 (40-5406) | |
| No. missing | 39 | 9 |
AML indicates acute myeloid leukemia; LDH, serum lactate dehydrogenase; MK, monosomal karyotype; PB, peripheral blood; and WBC, white blood count. Percentages may not add to 100 because of rounding.