Selection of genes differentially expressed in HSTL primary tumors compared with NKTCL (P < .001)
| Genes overexpressed in HSTL compared with NKTCL . | |
|---|---|
| Gene class and specific genes . | Fold change . |
| NK-cell–associated molecules | |
| KLRB1 | 17.26 |
| KLRG1 | 6.81 |
| Microenvironment | |
| Hemoglobin delta | 32.87 |
| Hemoglobin alpha | 22.79 |
| Hemoglobin beta | 19.46 |
| Hemoglobin gamma | 15.18 |
| CD36 | 14.63 |
| TCR | |
| TARP//TRGC2 | 11.12 |
| CD3D | 7.34 |
| CD3G | 6.89 |
| CD247 (CD3Z) | 3.82 |
| Chemokines | |
| CXCL7 | 23.27 |
| CXCL6 | 10.73 |
| Transcription factors | |
| NR4A2 | 17.77 |
| TCF21 | 11.72 |
| GATA6 | 6.16 |
| PRDM16 | 5.99 |
| PRDM1 | 2.81 |
| Signal transduction | |
| SPRY2 | 9.87 |
| PLCB1 | 9.66 |
| MAP4K3 | 7.81 |
| RHOB | 7.61 |
| SPRY1 | 5.59 |
| MAP3K5 | 2.35 |
| Wnt signaling | |
| TCF7L2 | 6.35 |
| TLE1 | 5.55 |
| Oncogenes | |
| VAV3 | 5.25 |
| FYN | 4.29 |
| MAF | 3.46 |
| Multidrug resistance | |
| ABCB1 | 2.54 |
| Growth factor | |
| PDGFD | 9.26 |
| Cell adhesion/ECM | |
| CD11d | 28.67 |
| ADAMTS17 | 9.53 |
| Apoptosis | |
| BCL2L11 | 4.59 |
| Cell cycle | |
| CCNL1 | 3.34 |
| CCND3 | 2.42 |
| Others | |
| S1PR5 | 39.64 |
| TMEM178 | 32.26 |
| TANC1 | 32.24 |
| FCRL3 | 20.27 |
| CD5L | 14.89 |
| CXXC5 | 14.83 |
| Genes overexpressed in HSTL compared with NKTCL . | |
|---|---|
| Gene class and specific genes . | Fold change . |
| NK-cell–associated molecules | |
| KLRB1 | 17.26 |
| KLRG1 | 6.81 |
| Microenvironment | |
| Hemoglobin delta | 32.87 |
| Hemoglobin alpha | 22.79 |
| Hemoglobin beta | 19.46 |
| Hemoglobin gamma | 15.18 |
| CD36 | 14.63 |
| TCR | |
| TARP//TRGC2 | 11.12 |
| CD3D | 7.34 |
| CD3G | 6.89 |
| CD247 (CD3Z) | 3.82 |
| Chemokines | |
| CXCL7 | 23.27 |
| CXCL6 | 10.73 |
| Transcription factors | |
| NR4A2 | 17.77 |
| TCF21 | 11.72 |
| GATA6 | 6.16 |
| PRDM16 | 5.99 |
| PRDM1 | 2.81 |
| Signal transduction | |
| SPRY2 | 9.87 |
| PLCB1 | 9.66 |
| MAP4K3 | 7.81 |
| RHOB | 7.61 |
| SPRY1 | 5.59 |
| MAP3K5 | 2.35 |
| Wnt signaling | |
| TCF7L2 | 6.35 |
| TLE1 | 5.55 |
| Oncogenes | |
| VAV3 | 5.25 |
| FYN | 4.29 |
| MAF | 3.46 |
| Multidrug resistance | |
| ABCB1 | 2.54 |
| Growth factor | |
| PDGFD | 9.26 |
| Cell adhesion/ECM | |
| CD11d | 28.67 |
| ADAMTS17 | 9.53 |
| Apoptosis | |
| BCL2L11 | 4.59 |
| Cell cycle | |
| CCNL1 | 3.34 |
| CCND3 | 2.42 |
| Others | |
| S1PR5 | 39.64 |
| TMEM178 | 32.26 |
| TANC1 | 32.24 |
| FCRL3 | 20.27 |
| CD5L | 14.89 |
| CXXC5 | 14.83 |
| Genes down-regulated in HSTL compared with NKTCL . | |
|---|---|
| Cytotoxic molecules | |
| Granzyme B | 0.15 |
| Granzyme K | 0.21 |
| Chemokines | |
| CXCL10 | 0.05 |
| Apoptosis | |
| BIRC5 | 0.26 |
| Immunomodulation | |
| IL4I1 | 0.26 |
| Tumor suppressor | |
| AIM1 | 0.26 |
| Genes down-regulated in HSTL compared with NKTCL . | |
|---|---|
| Cytotoxic molecules | |
| Granzyme B | 0.15 |
| Granzyme K | 0.21 |
| Chemokines | |
| CXCL10 | 0.05 |
| Apoptosis | |
| BIRC5 | 0.26 |
| Immunomodulation | |
| IL4I1 | 0.26 |
| Tumor suppressor | |
| AIM1 | 0.26 |
A complete list of genes is given in the supplemental Table 1.