Selection of genes differentially expressed in HSTL primary tumors compared with PTCL-NOS (P < .001)
| Genes overexpressed in HSTL compared with PTCL-NOS . | |
|---|---|
| Gene class and specific genes . | Fold change . |
| NK-cell–associated molecules | |
| KLRC3 | 73.95 |
| KIR2DS2 | 33.03 |
| KLRD1 | 25.39 |
| CD16 | 11.83 |
| KIR3DL2 | 21.58 |
| KLRB1 | 17.52 |
| KIR3DS1 | 16.88 |
| KIR2DL2 | 20.35 |
| KIR3DL1 | 19.85 |
| KIR2DL3 | 16.35 |
| KIR3DL3 | 18.95 |
| KIR2DL1 | 17.42 |
| KLRC4 | 14.41 |
| NCAM | 18.04 |
| CD244 | 10.65 |
| KIR2DS5 | 11.59 |
| KIR2DL5A | 12.02 |
| KIR2DS1 | 9.47 |
| KIR2DS3 | 9.05 |
| KLRG1 | 9.39 |
| KLRC1/KLRC2 | 10.37 |
| KIR2DL3/KIR2DL4/KIR2DL5A | 6.04 |
| CTSW (Cathepsin w) | 6.76 |
| KLRK1 | 6.45 |
| Microenvironment | |
| Hemoglobin gamma | 17.62 |
| Hemoglobin beta | 15.13 |
| Hemoglobin alpha | 14.39 |
| DEFA1/DEFA1B/DEFA3 | 13.64 |
| CCL3 (MIP1) | 4.44 |
| Chemokines | |
| CXCL7 (PPBP) | 21.06 |
| CXCL6 | 8.96 |
| Multidrug resistance | |
| ABCB1 (MDR1) | 11.72 |
| ABCB1/ABCB4 | 6.74 |
| Oncogenes | |
| MYBL1 | 18.81 |
| VAV3 | 3.86 |
| Cell adhesion/cell-cell interaction | |
| CD11d | 48.35 |
| PGM5 | 6.90 |
| TCR | |
| TRA@/TRD@ | 13.22 |
| TARP/TRGC2 | 10.94 |
| Transcription factors | |
| TCF21 | 12.87 |
| PRDM16 | 7.86 |
| WT1 | 3.70 |
| Growth factors | |
| IGFBP2 | 7.52 |
| AREG (amphiregulin) | 8.96 |
| PDGFD | 7.83 |
| ECM interaction | |
| ADAMTS17 | 12.93 |
| Others | |
| S1PR5 | 49.99 |
| Genes overexpressed in HSTL compared with PTCL-NOS . | |
|---|---|
| Gene class and specific genes . | Fold change . |
| NK-cell–associated molecules | |
| KLRC3 | 73.95 |
| KIR2DS2 | 33.03 |
| KLRD1 | 25.39 |
| CD16 | 11.83 |
| KIR3DL2 | 21.58 |
| KLRB1 | 17.52 |
| KIR3DS1 | 16.88 |
| KIR2DL2 | 20.35 |
| KIR3DL1 | 19.85 |
| KIR2DL3 | 16.35 |
| KIR3DL3 | 18.95 |
| KIR2DL1 | 17.42 |
| KLRC4 | 14.41 |
| NCAM | 18.04 |
| CD244 | 10.65 |
| KIR2DS5 | 11.59 |
| KIR2DL5A | 12.02 |
| KIR2DS1 | 9.47 |
| KIR2DS3 | 9.05 |
| KLRG1 | 9.39 |
| KLRC1/KLRC2 | 10.37 |
| KIR2DL3/KIR2DL4/KIR2DL5A | 6.04 |
| CTSW (Cathepsin w) | 6.76 |
| KLRK1 | 6.45 |
| Microenvironment | |
| Hemoglobin gamma | 17.62 |
| Hemoglobin beta | 15.13 |
| Hemoglobin alpha | 14.39 |
| DEFA1/DEFA1B/DEFA3 | 13.64 |
| CCL3 (MIP1) | 4.44 |
| Chemokines | |
| CXCL7 (PPBP) | 21.06 |
| CXCL6 | 8.96 |
| Multidrug resistance | |
| ABCB1 (MDR1) | 11.72 |
| ABCB1/ABCB4 | 6.74 |
| Oncogenes | |
| MYBL1 | 18.81 |
| VAV3 | 3.86 |
| Cell adhesion/cell-cell interaction | |
| CD11d | 48.35 |
| PGM5 | 6.90 |
| TCR | |
| TRA@/TRD@ | 13.22 |
| TARP/TRGC2 | 10.94 |
| Transcription factors | |
| TCF21 | 12.87 |
| PRDM16 | 7.86 |
| WT1 | 3.70 |
| Growth factors | |
| IGFBP2 | 7.52 |
| AREG (amphiregulin) | 8.96 |
| PDGFD | 7.83 |
| ECM interaction | |
| ADAMTS17 | 12.93 |
| Others | |
| S1PR5 | 49.99 |
| Genes down-regulated in HSTL compared with PTCL-NOS . | |
|---|---|
| Chemokines | |
| CCL19 | 0.011 |
| CXCL9 | 0.016 |
| CCL18 | 0.041 |
| CXCL10 | 0.044 |
| Genes down-regulated in HSTL compared with PTCL-NOS . | |
|---|---|
| Chemokines | |
| CCL19 | 0.011 |
| CXCL9 | 0.016 |
| CCL18 | 0.041 |
| CXCL10 | 0.044 |
| Gene class and specific genes . | Fold change . |
|---|---|
| TFH signature | |
| CXCL13 | 0.057 |
| CD200 | 0.165 |
| ICOS | 0.158 |
| CXCR5 | 0.246 |
| Immunomodulation | |
| IDO1 | 0.074 |
| IL4I1 | 0.160 |
| Tumor suppressor | |
| AIM1 | 0.195 |
| Others | |
| TIAM1 | 0.097 |
| CD5 | 0.209 |
| Gene class and specific genes . | Fold change . |
|---|---|
| TFH signature | |
| CXCL13 | 0.057 |
| CD200 | 0.165 |
| ICOS | 0.158 |
| CXCR5 | 0.246 |
| Immunomodulation | |
| IDO1 | 0.074 |
| IL4I1 | 0.160 |
| Tumor suppressor | |
| AIM1 | 0.195 |
| Others | |
| TIAM1 | 0.097 |
| CD5 | 0.209 |
A complete list of genes is given in the supplemental Table 1.