Characteristics of mAbs mapped to subdomains of the αIIb/β3 head structure
| Designation . | Specificity . | Reference . | ||
|---|---|---|---|---|
| Glycoprotein . | Domain . | Amino acids . | ||
| 10E5 | αIIb | Beta propeller | 77-82, 206, 208, 213-215 | 17 |
| 290.5 | αIIb | Beta propeller | ||
| 184.2 | αIIb | Beta propeller | ||
| 312.8 | αIIb | Beta propeller | 28 | |
| 312.2 | αIIb | Beta propeller | ||
| 312.6 | αIIb | Beta propeller | 28 | |
| PMI-1 | LIBS-αIIb | Calf-2 | 844-859 | 30 |
| 7E3 | β3 | Beta A | 129, 177-184 | 31 |
| AP2 | β3 | Beta A | ||
| AP3 | β3 | PSI/hybrid | 50-62 | 32 |
| 330.1 | β3 | PSI/hybrid | ||
| AP5 | LIBS-β3 | PSI | 1-6 | 24 |
| D3 | LIBS-β3 | Hybrid/EGF | 29 | |
| LIBS-6 | LIBS-β3 | EGF | 21 | |
| Designation . | Specificity . | Reference . | ||
|---|---|---|---|---|
| Glycoprotein . | Domain . | Amino acids . | ||
| 10E5 | αIIb | Beta propeller | 77-82, 206, 208, 213-215 | 17 |
| 290.5 | αIIb | Beta propeller | ||
| 184.2 | αIIb | Beta propeller | ||
| 312.8 | αIIb | Beta propeller | 28 | |
| 312.2 | αIIb | Beta propeller | ||
| 312.6 | αIIb | Beta propeller | 28 | |
| PMI-1 | LIBS-αIIb | Calf-2 | 844-859 | 30 |
| 7E3 | β3 | Beta A | 129, 177-184 | 31 |
| AP2 | β3 | Beta A | ||
| AP3 | β3 | PSI/hybrid | 50-62 | 32 |
| 330.1 | β3 | PSI/hybrid | ||
| AP5 | LIBS-β3 | PSI | 1-6 | 24 |
| D3 | LIBS-β3 | Hybrid/EGF | 29 | |
| LIBS-6 | LIBS-β3 | EGF | 21 | |
LIBS indicates ligand-induced binding site; PSI, plexin-semaphorin-integrin; and EGF, epidermal growth factor.