Comparison of high CRLF2-expressing SR cases with and without CRLF2 lesions
| NCI SR . | CRLF2 lesion (n = 49) . | no CRLF2 lesion (n = 41) . | P (log-rank) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of positive cases . | No. of evaluable cases . | Not determined . | % . | No. of positive cases . | No. of evaluable cases . | Not determined . | % . | ||
| Feature | |||||||||
| Age ≥ 10 y | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| WBC ≥ 50 000/μL | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| Male | 29 | 49 | 0 | 59.2 | 25 | 41 | 0 | 61.0 | > .999 |
| MRD ≥ .01% | 10 | 45 | 4 | 22.2 | 8 | 36 | 5 | 22.2 | > .999 |
| Relapsed | 10 | 49 | 0 | 20.4 | 7 | 41 | 0 | 17.1 | .790 |
| Chromosomes | |||||||||
| t(1;19) | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| t(12;21) | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| MLL | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| Trisomy 4 and 10 | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| Gain of CRLF2 locus* | 26 | 47 | 2 | 55.3 | 33 | 41 | 0 | 80.5 | .014 |
| DS | 17 | 49 | 0 | 34.7 | 2 | 39 | 0 | 5.1 | < .001 |
| JAK mutations | 12 | 45 | 4 | 26.7 | 1 | 37 | 4 | 2.7 | .005 |
| IKZF1 deletions/mutations | 14 | 34 | 15 | 41.2 | 10 | 29 | 12 | 34.5 | .613 |
| NCI SR . | CRLF2 lesion (n = 49) . | no CRLF2 lesion (n = 41) . | P (log-rank) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of positive cases . | No. of evaluable cases . | Not determined . | % . | No. of positive cases . | No. of evaluable cases . | Not determined . | % . | ||
| Feature | |||||||||
| Age ≥ 10 y | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| WBC ≥ 50 000/μL | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| Male | 29 | 49 | 0 | 59.2 | 25 | 41 | 0 | 61.0 | > .999 |
| MRD ≥ .01% | 10 | 45 | 4 | 22.2 | 8 | 36 | 5 | 22.2 | > .999 |
| Relapsed | 10 | 49 | 0 | 20.4 | 7 | 41 | 0 | 17.1 | .790 |
| Chromosomes | |||||||||
| t(1;19) | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| t(12;21) | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| MLL | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| Trisomy 4 and 10 | 0 | 49 | 0 | 0 | 0 | 41 | 0 | 0 | > .999 |
| Gain of CRLF2 locus* | 26 | 47 | 2 | 55.3 | 33 | 41 | 0 | 80.5 | .014 |
| DS | 17 | 49 | 0 | 34.7 | 2 | 39 | 0 | 5.1 | < .001 |
| JAK mutations | 12 | 45 | 4 | 26.7 | 1 | 37 | 4 | 2.7 | .005 |
| IKZF1 deletions/mutations | 14 | 34 | 15 | 41.2 | 10 | 29 | 12 | 34.5 | .613 |
Gain of CRLF2 locus determined by cytogenetics (+X or +Y) or FISH (extra copies of RP11-309M23).