Comparison of high CRLF2-expressing HR cases with and without CRLF2 lesions
| NCI HR . | CRLF2 lesion (n = 44) . | No CRLF2 lesion (n = 47) . | P (log-rank) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of positive cases . | No. of evaluable cases . | Not determined . | % . | No. of positive cases . | No. of evaluable cases . | Not determined . | % . | ||
| Feature | |||||||||
| Age ≥ 10 y | 29 | 44 | 0 | 65.9 | 30 | 47 | 0 | 63.8 | > .999 |
| WBC ≥ 50 000/μL | 26 | 44 | 0 | 59.1 | 24 | 47 | 0 | 51.1 | .529 |
| Male | 24 | 44 | 0 | 54.5 | 25 | 47 | 0 | 53.2 | > .999 |
| MRD ≥ .01% | 18 | 41 | 3 | 43.9 | 14 | 43 | 4 | 32.6 | .370 |
| Relapsed | 28 | 44 | 0 | 63.6 | 24 | 47 | 0 | 51.1 | .290 |
| Chromosomes | |||||||||
| t(1;19) | 0 | 44 | 0 | 0 | 0 | 47 | 0 | 0 | > .999 |
| t(12;21) | 0 | 44 | 0 | 0 | 0 | 47 | 0 | 0 | > .999 |
| MLL | 0 | 44 | 0 | 0 | 1 | 47 | 0 | 2.1 | > .999 |
| Trisomy 4 and 10 | 5 | 43 | 1 | 11.6 | 22 | 47 | 0 | 46.8 | < .001 |
| Gain of CRLF2 locus* | 16 | 32 | 12 | 50.0 | 26 | 47 | 0 | 55.3 | .654 |
| DS | 4 | 39 | 5 | 10.3 | 3 | 43 | 4 | 7.0 | .703 |
| JAK mutations | 23 | 42 | 2 | 54.8 | 1 | 43 | 4 | 2.3 | < .001 |
| IKZF1 deletions/mutations | 25 | 37 | 7 | 67.6 | 12 | 38 | 9 | 31.6 | .003 |
| NCI HR . | CRLF2 lesion (n = 44) . | No CRLF2 lesion (n = 47) . | P (log-rank) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| No. of positive cases . | No. of evaluable cases . | Not determined . | % . | No. of positive cases . | No. of evaluable cases . | Not determined . | % . | ||
| Feature | |||||||||
| Age ≥ 10 y | 29 | 44 | 0 | 65.9 | 30 | 47 | 0 | 63.8 | > .999 |
| WBC ≥ 50 000/μL | 26 | 44 | 0 | 59.1 | 24 | 47 | 0 | 51.1 | .529 |
| Male | 24 | 44 | 0 | 54.5 | 25 | 47 | 0 | 53.2 | > .999 |
| MRD ≥ .01% | 18 | 41 | 3 | 43.9 | 14 | 43 | 4 | 32.6 | .370 |
| Relapsed | 28 | 44 | 0 | 63.6 | 24 | 47 | 0 | 51.1 | .290 |
| Chromosomes | |||||||||
| t(1;19) | 0 | 44 | 0 | 0 | 0 | 47 | 0 | 0 | > .999 |
| t(12;21) | 0 | 44 | 0 | 0 | 0 | 47 | 0 | 0 | > .999 |
| MLL | 0 | 44 | 0 | 0 | 1 | 47 | 0 | 2.1 | > .999 |
| Trisomy 4 and 10 | 5 | 43 | 1 | 11.6 | 22 | 47 | 0 | 46.8 | < .001 |
| Gain of CRLF2 locus* | 16 | 32 | 12 | 50.0 | 26 | 47 | 0 | 55.3 | .654 |
| DS | 4 | 39 | 5 | 10.3 | 3 | 43 | 4 | 7.0 | .703 |
| JAK mutations | 23 | 42 | 2 | 54.8 | 1 | 43 | 4 | 2.3 | < .001 |
| IKZF1 deletions/mutations | 25 | 37 | 7 | 67.6 | 12 | 38 | 9 | 31.6 | .003 |
Gain of CRLF2 locus determined by cytogenetics (+X or +Y) or FISH (extra copies of RP11-309M23).