Table 3 CRLF2 genomic rearrangements and... | American Society of Hematology

Table 3

CRLF2 genomic rearrangements and mutations in cases with high CRLF2 expression

Feature	High CRLF2 (n = 186)				NCI HR (n = 95)				NCI SR (n = 91)				P (log-rank)
Feature	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	P (log-rank)
CRLF2 genomic rearrangements
IGH@-CRLF2	31	178	8	17.4	22	90	5	24.4	9	88	3	10.2	.017
P2RY8-CRLF2	65	183	3	35.5	24	92	3	26.1	41	91	0	45.1	.009
Either lesion*	93	181	5	51.4	44	91	4	48.4	49	90	1	54.4	.458
CRLF2 (F232C)	3	134	52	2.2	0	45	50	0.0	3	89	2	3.4	.551
Gain of locus†	102	168	18	60.7	43	80	15	53.8	59	88	3	67.0	.084
JAK and IL7R mutations
Any JAK‡	37	170	16	21.8	24	88	7	27.3	13	82	9	15.9	.094
IL7R mutation	1	141	45	0.7	0	76	19	0.0	1	65	26	1.5	.461
IKZF1 event§	61	141	45	43.3	37	78	17	47.4	24	63	28	38.1	.307

Feature	High CRLF2 (n = 186)				NCI HR (n = 95)				NCI SR (n = 91)				P (log-rank)
Feature	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	P (log-rank)
CRLF2 genomic rearrangements
IGH@-CRLF2	31	178	8	17.4	22	90	5	24.4	9	88	3	10.2	.017
P2RY8-CRLF2	65	183	3	35.5	24	92	3	26.1	41	91	0	45.1	.009
Either lesion*	93	181	5	51.4	44	91	4	48.4	49	90	1	54.4	.458
CRLF2 (F232C)	3	134	52	2.2	0	45	50	0.0	3	89	2	3.4	.551
Gain of locus†	102	168	18	60.7	43	80	15	53.8	59	88	3	67.0	.084
JAK and IL7R mutations
Any JAK‡	37	170	16	21.8	24	88	7	27.3	13	82	9	15.9	.094
IL7R mutation	1	141	45	0.7	0	76	19	0.0	1	65	26	1.5	.461
IKZF1 event§	61	141	45	43.3	37	78	17	47.4	24	63	28	38.1	.307

Either IGH@-CRLF2 or P2RY8-CRLF2.

Gain of CRLF2 locus determined by cytogenetics (+X or +Y) or FISH (extra copies of RP11-309M23).

Mutation of JAK1, JAK2, or JAK3.

Mutation or deletion of IKZF1.