Table 2 CRLF2 genomic rearrangements and... | American Society of Hematology

Table 2

CRLF2 genomic rearrangements and mutations in cases tested for CRLF2 lesions

Feature	ALL cases tested (n = 304)				NCI HR (n = 141)				NCI SR (n = 163)				P (log-rank)
Feature	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	P (log-rank)
High CRLF2 expression	181	304	0	59.5	91	141	0	64.5	90	163	0	55.2	.103
CRLF2 genomic rearrangements and mutations
IGH@-CRLF2	31	301	3	10.3	22	140	1	15.7	9	161	2	5.6	.004
P2RY8-CRLF2	65	304	0	21.4	24	141	0	17.0	41	163	0	25.2	.093
Either lesion*	93	304	0	30.6	44	141	0	31.2	49	163	0	30.1	.901
CRLF2 (F232C)	3	142	162	2.1	0	53	88	0.0	3	89	74	3.4	.293
Gain of locus†	140	284	20	49.3	55	124	17	4.4	85	160	3	53.1	.153

Feature	ALL cases tested (n = 304)				NCI HR (n = 141)				NCI SR (n = 163)				P (log-rank)
Feature	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	No. of positive cases	No. of evaluable cases	Not determined	%	P (log-rank)
High CRLF2 expression	181	304	0	59.5	91	141	0	64.5	90	163	0	55.2	.103
CRLF2 genomic rearrangements and mutations
IGH@-CRLF2	31	301	3	10.3	22	140	1	15.7	9	161	2	5.6	.004
P2RY8-CRLF2	65	304	0	21.4	24	141	0	17.0	41	163	0	25.2	.093
Either lesion*	93	304	0	30.6	44	141	0	31.2	49	163	0	30.1	.901
CRLF2 (F232C)	3	142	162	2.1	0	53	88	0.0	3	89	74	3.4	.293
Gain of locus†	140	284	20	49.3	55	124	17	4.4	85	160	3	53.1	.153

Either IGH@-CRLF2 or P2RY8-CRLF2.

Gain of CRLF2 locus determined by cytogenetics (+X or +Y) or FISH (extra copies of RP11-309M23).