Parameters of thrombosis, inflammation, and oxidative stress in the APS patients and the controls
| . | APS patients (n = 43) . | Healthy donors (n = 38) . | P . |
|---|---|---|---|
| Prothrombotic and proinflammatory parameters | |||
| TF, % | |||
| Monocytes | 47.13 ± 23.08 | 28.39 ± 22.20 | .03 |
| Neutrophils | 20.99 ± 19.14 | 12.28 ± 11.14 | n.s. |
| PAR2, % | |||
| Monocytes | 10.55 ± 8.9 | 5.90 ± 3.60 | .024 |
| Neutrophils | 2.25 ± 1.27 | 2.13 ± 1.71 | n.s. |
| VEGF-R1, % | |||
| Monocytes | 70.84 ± 24.62 | 50.06 ± 31.81 | .011 |
| Neutrophils | 61.47 ± 51.39 | 34.17 ± 27.61 | n.s. |
| VEGF-A, pg/mL | 605.26 ± 500.73 | 347.29 ± 221.33 | .047 |
| sCD40L, ng/mL | 16.32 ± 22.16 | 22.85 ± 19.30 | n.s. |
| IFN-α, pg/mL | 87.60 ± 145.71 | 168.47 ± 258.58 | n.s. |
| IFN-γ, pg/mL | 1.89 ± 6.29 | 5.46 ± 11.50 | n.s. |
| IL-6, pg/mL | 0.03 ± 0.10 | 0.11 ± 0.15 | n.s. |
| IL-8, pg/mL | 25.20 ± 52.70 | 4.10 ± 13.40 | .030 |
| IL-10, pg/mL | 22.30 ± 61.20 | 35.69 ± 79.49 | n.s. |
| MCP-1, pg/mL | 627.10 ± 251.60 | 486.79 ± 157.14 | .016 |
| MIP1-α, pg/mL | 455.80 ± 509.20 | 192.58 ± 273.86 | .016 |
| soluble P-selectin, ng/mL | 193.19 ± 75.28 | 183.52 ± 69.60 | n.s. |
| tPA, ng/mL | 2.54 ± 1.40 | 1.90 ± 0.82 | .049 |
| Oxidative status in plasma and monocytes | |||
| TAC, plasma; mM Trolox equivalent | 103.57 ± 44.9 | 147.12 ± 54.78 | .005 |
| NO, plasma, μM | 15.76 ± 7.97 | 21.75 ± 12.09 | .035 |
| Nitrotyrosine, μM | 729.10 ± 695.76 | 196.75 ± 201.41 | .010 |
| Manganese-SOD, U/min/mL/μg protein | 0.24 ± 0.19 | 0.11 ± 0.11 | .019 |
| Catalase, nmoL/min/mL/μg protein | 122.11 ± 90.91 | 211.69 ± 111.81 | .025 |
| GPx, nmoL/min/mL/μg protein | 1.19 ± 0.60 | 2.33 ± 0.97 | .009 |
| . | APS patients (n = 43) . | Healthy donors (n = 38) . | P . |
|---|---|---|---|
| Prothrombotic and proinflammatory parameters | |||
| TF, % | |||
| Monocytes | 47.13 ± 23.08 | 28.39 ± 22.20 | .03 |
| Neutrophils | 20.99 ± 19.14 | 12.28 ± 11.14 | n.s. |
| PAR2, % | |||
| Monocytes | 10.55 ± 8.9 | 5.90 ± 3.60 | .024 |
| Neutrophils | 2.25 ± 1.27 | 2.13 ± 1.71 | n.s. |
| VEGF-R1, % | |||
| Monocytes | 70.84 ± 24.62 | 50.06 ± 31.81 | .011 |
| Neutrophils | 61.47 ± 51.39 | 34.17 ± 27.61 | n.s. |
| VEGF-A, pg/mL | 605.26 ± 500.73 | 347.29 ± 221.33 | .047 |
| sCD40L, ng/mL | 16.32 ± 22.16 | 22.85 ± 19.30 | n.s. |
| IFN-α, pg/mL | 87.60 ± 145.71 | 168.47 ± 258.58 | n.s. |
| IFN-γ, pg/mL | 1.89 ± 6.29 | 5.46 ± 11.50 | n.s. |
| IL-6, pg/mL | 0.03 ± 0.10 | 0.11 ± 0.15 | n.s. |
| IL-8, pg/mL | 25.20 ± 52.70 | 4.10 ± 13.40 | .030 |
| IL-10, pg/mL | 22.30 ± 61.20 | 35.69 ± 79.49 | n.s. |
| MCP-1, pg/mL | 627.10 ± 251.60 | 486.79 ± 157.14 | .016 |
| MIP1-α, pg/mL | 455.80 ± 509.20 | 192.58 ± 273.86 | .016 |
| soluble P-selectin, ng/mL | 193.19 ± 75.28 | 183.52 ± 69.60 | n.s. |
| tPA, ng/mL | 2.54 ± 1.40 | 1.90 ± 0.82 | .049 |
| Oxidative status in plasma and monocytes | |||
| TAC, plasma; mM Trolox equivalent | 103.57 ± 44.9 | 147.12 ± 54.78 | .005 |
| NO, plasma, μM | 15.76 ± 7.97 | 21.75 ± 12.09 | .035 |
| Nitrotyrosine, μM | 729.10 ± 695.76 | 196.75 ± 201.41 | .010 |
| Manganese-SOD, U/min/mL/μg protein | 0.24 ± 0.19 | 0.11 ± 0.11 | .019 |
| Catalase, nmoL/min/mL/μg protein | 122.11 ± 90.91 | 211.69 ± 111.81 | .025 |
| GPx, nmoL/min/mL/μg protein | 1.19 ± 0.60 | 2.33 ± 0.97 | .009 |
Values are mean ± SD.