Table 4 Response by baseline mutation... | American Society of Hematology

Table 4

Response by baseline mutation status

Mutation status	n	Cumulative response, n/n evaluable (%)
Mutation status	n	CHR	MCyR
No mutation	44	34/44 (77)	15/43 (35)
Any mutation	39	26/39 (67)	11/35 (31)
> 1 mutation	9	3/9 (33)	2/9 (22)
Mutation type*
P-loop†	14	9/14 (64)	4/13 (31)
G250E	6	3/6	0/5
Y253H	6	5/6	4/6
E255K	1	0/1	0/1
E255V	1	1/1	0/1
Non–P-loop‡	29	18/29 (62)	9/26 (35)
M244V	3	3/3	2/3
V299L	2	1/2	0/2
Q300R	1	1/1	1/1
T315I	7	2/7	0/6
F317L	8	4/8	1/7
N336S	1	1/1	0/1
M351T	1	1/1	0/1
F359C	2	2/2	1/2
F359I	2	2/2	2/2
F359V	2	0/2	1/2
L387F	1	1/1	0/1
H396R	1	0/1	0/1
E453A	1	1/1	0/0
C475V	1	1/1	1/1
F486S	1	0/1	0/1

Mutation status	n	Cumulative response, n/n evaluable (%)
Mutation status	n	CHR	MCyR
No mutation	44	34/44 (77)	15/43 (35)
Any mutation	39	26/39 (67)	11/35 (31)
> 1 mutation	9	3/9 (33)	2/9 (22)
Mutation type*
P-loop†	14	9/14 (64)	4/13 (31)
G250E	6	3/6	0/5
Y253H	6	5/6	4/6
E255K	1	0/1	0/1
E255V	1	1/1	0/1
Non–P-loop‡	29	18/29 (62)	9/26 (35)
M244V	3	3/3	2/3
V299L	2	1/2	0/2
Q300R	1	1/1	1/1
T315I	7	2/7	0/6
F317L	8	4/8	1/7
N336S	1	1/1	0/1
M351T	1	1/1	0/1
F359C	2	2/2	1/2
F359I	2	2/2	2/2
F359V	2	0/2	1/2
L387F	1	1/1	0/1
H396R	1	0/1	0/1
E453A	1	1/1	0/0
C475V	1	1/1	1/1
F486S	1	0/1	0/1

Patients with > 1 mutation may be counted in both the P-loop and non–P-loop categories.

P-loop mutations include those from positions 248 to 255.

Non–P-loop mutations include those from positions 244 to 247 and > 255.