Table 1

Affinity measurements of A2-SL9–specific TCRs

TCRKon, 1/MsKoff, 1/sKD, nMT1/2
a2/b1 1.6 × 105 0.139 870 4.9 sec 
aWT/bWT 2.6 × 105 2.2 × 10−2 85 30 sec 
a11/bWT 7.4 × 104 1.1 × 10−3 14.9 10.5 min 
aWT/b6 1.2 × 105 7.6 × 10−4 6.6 15.1 min 
a11/b6 2.25 × 105 5.4 × 10−5 0.245 213.9 min 
TCRKon, 1/MsKoff, 1/sKD, nMT1/2
a2/b1 1.6 × 105 0.139 870 4.9 sec 
aWT/bWT 2.6 × 105 2.2 × 10−2 85 30 sec 
a11/bWT 7.4 × 104 1.1 × 10−3 14.9 10.5 min 
aWT/b6 1.2 × 105 7.6 × 10−4 6.6 15.1 min 
a11/b6 2.25 × 105 5.4 × 10−5 0.245 213.9 min 

Kon indicates on rate; Koff, off rate; KD, affinity constant; and T1/2, half life.

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