Incidence of chromosomal breakpoints in unselected series of diffuse large B cell lymphoma
| Study . | N* . | MYC+ total, n (%) . | MYC+ SH, n (%) . | BCL2+/MYC+ DH, n (%) . | BCL6+/MYC+ DH, n (%) . | BCL2+/BCL6+/MYC+ TH, n (%) . | All DH and TH, n (%) . | All DH & TH / MYC cases, n/N (%) . | BCL2+ SH, n (%) . | BCL6+ SH, n (%) . |
|---|---|---|---|---|---|---|---|---|---|---|
| Barrans et al114 2010† | 245-264 | 35 (14) | 6 (2) | 19 (8) | 3 (1) | 7 (3) | 29 (12) | 29/35 (83) | 55 (21) | 64 (24) |
| Obermann et al130 2009‡ | 220 | 9 (4) | 7 (3) | 1 (0) | 1 (0) | 0 | 2 (1)§ | 2/9 (22) | NA | NA |
| Yoon et al129 2008‡ | 137-156 | 14 (7) | 11 (7) | 1 (1) | 1 (1) | 1 (1) | 3 (3) | 3/14 (21) | 3 (2) | 22 (16) |
| Tibiletti et al131 2009†‖ | 74 | 12 (16) | 3 (4) | 4 (7) | 4 (7) | 1 (1) | 9 (12) | 9/12 (75) | 12 (15) | 30 (39) |
| Copie-Bergman et al132 2009‡ | 68-71 | 2 (3) | 2 (3) | 0 | 0 | 0 | 0 | 0 | 14 (20) | 21 (30) |
| van Imhoff et al133 2006†¶ | 58-59 | 9 (15) | 5 (8) | 3 (5) | 1 (2) | 0 | 4 (7) | 4/9 (44) | 7 (12) | 14 (24) |
| Savage et al128 2009‡ | 135 | 12 (9) | 9 (7) | 3 (2) | NA | NA | NA | 3/12 (25) | NA | NA |
| Klapper et al108 2008‡# | 117 | 14 (8) | NA | NA | NA | NA | NA | NA | NA | NA |
| Study . | N* . | MYC+ total, n (%) . | MYC+ SH, n (%) . | BCL2+/MYC+ DH, n (%) . | BCL6+/MYC+ DH, n (%) . | BCL2+/BCL6+/MYC+ TH, n (%) . | All DH and TH, n (%) . | All DH & TH / MYC cases, n/N (%) . | BCL2+ SH, n (%) . | BCL6+ SH, n (%) . |
|---|---|---|---|---|---|---|---|---|---|---|
| Barrans et al114 2010† | 245-264 | 35 (14) | 6 (2) | 19 (8) | 3 (1) | 7 (3) | 29 (12) | 29/35 (83) | 55 (21) | 64 (24) |
| Obermann et al130 2009‡ | 220 | 9 (4) | 7 (3) | 1 (0) | 1 (0) | 0 | 2 (1)§ | 2/9 (22) | NA | NA |
| Yoon et al129 2008‡ | 137-156 | 14 (7) | 11 (7) | 1 (1) | 1 (1) | 1 (1) | 3 (3) | 3/14 (21) | 3 (2) | 22 (16) |
| Tibiletti et al131 2009†‖ | 74 | 12 (16) | 3 (4) | 4 (7) | 4 (7) | 1 (1) | 9 (12) | 9/12 (75) | 12 (15) | 30 (39) |
| Copie-Bergman et al132 2009‡ | 68-71 | 2 (3) | 2 (3) | 0 | 0 | 0 | 0 | 0 | 14 (20) | 21 (30) |
| van Imhoff et al133 2006†¶ | 58-59 | 9 (15) | 5 (8) | 3 (5) | 1 (2) | 0 | 4 (7) | 4/9 (44) | 7 (12) | 14 (24) |
| Savage et al128 2009‡ | 135 | 12 (9) | 9 (7) | 3 (2) | NA | NA | NA | 3/12 (25) | NA | NA |
| Klapper et al108 2008‡# | 117 | 14 (8) | NA | NA | NA | NA | NA | NA | NA | NA |
All cases had DLBCL as morphology.
SH indicates single hit; DH, double hit; TH, triple hit; and NA, not available.
Number of cases on which FISH was performed; variable numbers because of some failures in individual tests.
FISH on conventional tissue sections.
FISH on tissue microarray.
Original paper included 1 CCND1+/MYC+ DH that is not shown in table.
DLBCL was selected for primary nodal localization.
Cases from clinical trials were selected for patients with poor-risk DLBCL.
No FISH for BCL2 and BCL6 was performed in the study.