Association of the DNMT3 mutation with other gene mutations
| Variable . | Patients with alteration, n (%) . | P . | ||
|---|---|---|---|---|
| Whole cohort (n = 500) . | DNMT3A-mutated patients (n = 70) . | DNMT3A-wild patients (n = 430) . | ||
| FLT3/ITD | 113 (22.6) | 30 (42.9) | 83 (19.3) | < .0001 |
| FLT3/TKD | 39 (7.8) | 9 (12.9) | 29 (6.7) | .087 |
| N-RAS | 61 (12.2) | 8 (11.4) | 53 (12.3) | > .9999 |
| K-RAS | 16 (3.2) | 1 (1.4) | 15 (3.5) | .7112 |
| PTPN11 | 18 (3.6) | 7 (10) | 11 (2.6) | .007 |
| KIT | 15 (3.0) | 0 (0) | 15 (3.5) | .2451 |
| JAK2 | 3 (0.6) | 0 (0) | 3 (0.7) | > .9999 |
| WTI | 33 (6.6) | 2 (2.9) | 31 (7.2) | .2946 |
| NPM1 | 104 (20.8) | 38 (54.3) | 66 (15.3) | < .0001 |
| CEBPA | 66 (13.2) | 3 (4.3) | 63 (14.7) | .0134 |
| AML1/RUNX1 | 62 (12.4) | 8 (11.4) | 54 (12.6) | > .9999 |
| MLL/PTD | 27 (5.4) | 6 (8.6) | 21 (4.9) | .2475 |
| ASXL1 | 51 (10.2) | 4 (5.7) | 46 (10.7) | .2812 |
| IDH1 | 27 (5.4) | 4 (5.7) | 23 (5.3) | .7812 |
| IDH2 | 55 (11) | 16 (22.9) | 39 (9.1) | .0016 |
| TET2 | 65 (13.0) | 6 (8.6) | 59 (13.7) | .3365 |
| Variable . | Patients with alteration, n (%) . | P . | ||
|---|---|---|---|---|
| Whole cohort (n = 500) . | DNMT3A-mutated patients (n = 70) . | DNMT3A-wild patients (n = 430) . | ||
| FLT3/ITD | 113 (22.6) | 30 (42.9) | 83 (19.3) | < .0001 |
| FLT3/TKD | 39 (7.8) | 9 (12.9) | 29 (6.7) | .087 |
| N-RAS | 61 (12.2) | 8 (11.4) | 53 (12.3) | > .9999 |
| K-RAS | 16 (3.2) | 1 (1.4) | 15 (3.5) | .7112 |
| PTPN11 | 18 (3.6) | 7 (10) | 11 (2.6) | .007 |
| KIT | 15 (3.0) | 0 (0) | 15 (3.5) | .2451 |
| JAK2 | 3 (0.6) | 0 (0) | 3 (0.7) | > .9999 |
| WTI | 33 (6.6) | 2 (2.9) | 31 (7.2) | .2946 |
| NPM1 | 104 (20.8) | 38 (54.3) | 66 (15.3) | < .0001 |
| CEBPA | 66 (13.2) | 3 (4.3) | 63 (14.7) | .0134 |
| AML1/RUNX1 | 62 (12.4) | 8 (11.4) | 54 (12.6) | > .9999 |
| MLL/PTD | 27 (5.4) | 6 (8.6) | 21 (4.9) | .2475 |
| ASXL1 | 51 (10.2) | 4 (5.7) | 46 (10.7) | .2812 |
| IDH1 | 27 (5.4) | 4 (5.7) | 23 (5.3) | .7812 |
| IDH2 | 55 (11) | 16 (22.9) | 39 (9.1) | .0016 |
| TET2 | 65 (13.0) | 6 (8.6) | 59 (13.7) | .3365 |