Association of DNMT3A mutation with chromosomal abnormalities
| . | Total . | DNMT3A-mutated . | DNMT3A-wild . | P . |
|---|---|---|---|---|
| Karyotype* | .0069 | |||
| Favorable | 99 | 0 (0) | 99 (100) | < .0001 |
| Intermediate | 318 | 62 (19.5) | 256 (80.5) | < .0001 |
| Unfavorable | 65 | 4 (6.2) | 61 (93.8) | .0783 |
| Unknown | 18 | 4 (22.2) | 14 (77.7) | |
| Normal | 223 | 51 (22.9) | 172 (77.1) | < .0001 |
| Simple | 208 | 13 (6.2) | 195 (93.8) | < .0001 |
| Complex | 51 | 2 (3.9) | 49 (96.1) | .0303 |
| t(8;21) | 42 | 0 (0) | 42 (100) | .0034 |
| t(15;17) | 38 | 0 (0) | 38 (100) | .0053 |
| inv(16) | 19 | 0 (0) | 19 (100) | .0909 |
| t(11q23) | 16 | 0 (0) | 16 (100) | .145 |
| t(7;11) | 10 | 0 (0) | 10 (100) | .371 |
| −5/5q−† | 2 | 1 (50) | 1 (50) | .2554 |
| −7/7q−† | 10 | 1 (10) | 9 (90) | > .9999 |
| +8‡ | 27 | 4 (14.8) | 23 (85.2) | .7765 |
| +11† | 3 | 1 (33.3) | 2 (66.7) | .3577 |
| +13† | 1 | 0 (0) | 1 (100) | > .9999 |
| +21† | 9 | 0 (0) | 9 (100) | .6178 |
| . | Total . | DNMT3A-mutated . | DNMT3A-wild . | P . |
|---|---|---|---|---|
| Karyotype* | .0069 | |||
| Favorable | 99 | 0 (0) | 99 (100) | < .0001 |
| Intermediate | 318 | 62 (19.5) | 256 (80.5) | < .0001 |
| Unfavorable | 65 | 4 (6.2) | 61 (93.8) | .0783 |
| Unknown | 18 | 4 (22.2) | 14 (77.7) | |
| Normal | 223 | 51 (22.9) | 172 (77.1) | < .0001 |
| Simple | 208 | 13 (6.2) | 195 (93.8) | < .0001 |
| Complex | 51 | 2 (3.9) | 49 (96.1) | .0303 |
| t(8;21) | 42 | 0 (0) | 42 (100) | .0034 |
| t(15;17) | 38 | 0 (0) | 38 (100) | .0053 |
| inv(16) | 19 | 0 (0) | 19 (100) | .0909 |
| t(11q23) | 16 | 0 (0) | 16 (100) | .145 |
| t(7;11) | 10 | 0 (0) | 10 (100) | .371 |
| −5/5q−† | 2 | 1 (50) | 1 (50) | .2554 |
| −7/7q−† | 10 | 1 (10) | 9 (90) | > .9999 |
| +8‡ | 27 | 4 (14.8) | 23 (85.2) | .7765 |
| +11† | 3 | 1 (33.3) | 2 (66.7) | .3577 |
| +13† | 1 | 0 (0) | 1 (100) | > .9999 |
| +21† | 9 | 0 (0) | 9 (100) | .6178 |
Four hundred eighty-two patients, including 66 DNMT3A-mutated and 416 DNMT3A-wild patients, had chromosome data at diagnosis.
Favorable, t(15;17), t(8;21), inv(16); unfavorable, −7, del(7q), −5, del(5q), 3q abnormality, complex abnormalities; and intermediate, normal karyotype and other abnormalities.
Only including simple chromosomal abnormalities with ≤ 2 changes, but not those with complex abnormalities with ≥ 3 aberrations.