Multivariate analysis: adjusted hazard ratio (Cox model)
| Risk factors . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| sTK | 2.98 | 1.65-5.41 | < 10−4 |
| Lymphocytosis | 1.74 | 1.03-2.95 | .01 |
| β2-microbulin | 3.17 | 1.722-5.84 | < 10−4 |
| CD38 | 1.86 | 1.03-3.38 | .01 |
| Risk factors . | Hazard ratio . | 95% CI . | P . |
|---|---|---|---|
| sTK | 2.98 | 1.65-5.41 | < 10−4 |
| Lymphocytosis | 1.74 | 1.03-2.95 | .01 |
| β2-microbulin | 3.17 | 1.722-5.84 | < 10−4 |
| CD38 | 1.86 | 1.03-3.38 | .01 |
Cutoff values for patient dichotomization were median values for lymphocytosis and β2-microbulin, that is, 13 G/L and 2.5 mg/L, respectively. For sTK, the cutoff value was set at 10 to be in concordance with the value chosen to stratify patients in clinical trials, in particular in the French-German CLL7 trial for stage A CLL (NCT00275054).
CI indicates confidence interval; and sTK, serum thymidine kinase.