Table 2 Univariate and multivariate... | American Society of Hematology

Table 2

Univariate and multivariate analysis for overall survival in the CLL training series

Characteristics	Event	Total	OS, y			Univariate analysis				Multivariate analysis*†‡				Internal bootstrapping validation
			OS, y			Univariate analysis				Multivariate analysis*†‡				Bootstrap parameter, mean			Bootstrap selection, %
			Median	LCI	UCI	HR	LCI	UCI	P	HR	LCI	UCI	P	HR	LCI	UCI	Bootstrap selection, %
Age§						1.06	1.03	1.08	< .001	1.07	1.04	1.10	< .001	1.07	1.05	1.10	100
Female	29	139	13.9	10.8	17.0
Male	49	170	12.2	8.0	16.5	1.53	.096	2.43	.069	1.96	1.20	3.20	.007	2.17	1.28	3.68	91.1
NOTCH1 germline	62	275	13.9	10.5	17.3
NOTCH1 mutations	16	34	3.5	0	7.3	3.77	2.14	6.66	< .001	3.99	2.05	7.76	< .001	4.55	2.23	9.31	98.0
Rai stage 0-II	55	275	15.6	13.1	18.7
Rai stage III-IV	23	34	6.0	2.5	9.6	3.99	2.44	6.50	< .001	2.33	1.25	3.99	.007	2.57	1.38	4.82	90.0
IGHV identity < 98%	42	206	NR
IGHV identity ≥ 98%	36	103	11.7	6.3	17.2	2.23	1.42	3.52	.001	1.44	0.83	2.50	.191	1.53	0.86	2.71	50.4
No trisomy 12	52	248	NR
Trisomy 12	26	61	10.8	5.5	16.0	1.93	1.21	3.01	.006	1.50	0.91	2.64	.108	1.62	0.96	2.74	55.4
No 11q22-q23 deletion	65	284	15.6	13.3	17.9
11q22-q23 deletion	13	25	6.8	0	14.1	2.25	1.23	4.11	.008	1.57	0.76	3.27	.220	1.77	0.81	3.90	47.4
TP53 germline	61	276	13.9	10.5	17.3
TP53 disruption	17	33	4.6	1.8	7.3	3.74	2.16	6.49	< .001	3.27	1.80	5.95	< .001	3.38	1.78	6.43	96.5

Characteristics	Event	Total	OS, y			Univariate analysis				Multivariate analysis*†‡				Internal bootstrapping validation
			OS, y			Univariate analysis				Multivariate analysis*†‡				Bootstrap parameter, mean			Bootstrap selection, %
			Median	LCI	UCI	HR	LCI	UCI	P	HR	LCI	UCI	P	HR	LCI	UCI	Bootstrap selection, %
Age§						1.06	1.03	1.08	< .001	1.07	1.04	1.10	< .001	1.07	1.05	1.10	100
Female	29	139	13.9	10.8	17.0
Male	49	170	12.2	8.0	16.5	1.53	.096	2.43	.069	1.96	1.20	3.20	.007	2.17	1.28	3.68	91.1
NOTCH1 germline	62	275	13.9	10.5	17.3
NOTCH1 mutations	16	34	3.5	0	7.3	3.77	2.14	6.66	< .001	3.99	2.05	7.76	< .001	4.55	2.23	9.31	98.0
Rai stage 0-II	55	275	15.6	13.1	18.7
Rai stage III-IV	23	34	6.0	2.5	9.6	3.99	2.44	6.50	< .001	2.33	1.25	3.99	.007	2.57	1.38	4.82	90.0
IGHV identity < 98%	42	206	NR
IGHV identity ≥ 98%	36	103	11.7	6.3	17.2	2.23	1.42	3.52	.001	1.44	0.83	2.50	.191	1.53	0.86	2.71	50.4
No trisomy 12	52	248	NR
Trisomy 12	26	61	10.8	5.5	16.0	1.93	1.21	3.01	.006	1.50	0.91	2.64	.108	1.62	0.96	2.74	55.4
No 11q22-q23 deletion	65	284	15.6	13.3	17.9
11q22-q23 deletion	13	25	6.8	0	14.1	2.25	1.23	4.11	.008	1.57	0.76	3.27	.220	1.77	0.81	3.90	47.4
TP53 germline	61	276	13.9	10.5	17.3
TP53 disruption	17	33	4.6	1.8	7.3	3.74	2.16	6.49	< .001	3.27	1.80	5.95	< .001	3.38	1.78	6.43	96.5

LCI indicates 95% lower confidence interval; UCI, 95% upper confidence interval; and NR, not reached.

Shrinkage coefficient, 0.91.

Discrimination: c-index of the original model, 0.792; bias-corrected c-index, 0.015; and optimism, 0.777.

Calibration: calibration slope of the original model, 1.000; bias-corrected calibration slope, 0.910; and optimism, 0.090.

Age was treated as a continuous variable.