Characteristics of the CLL training series according to NOTCH1 mutation status
| Characteristic . | All (n = 309) . | NOTCH1 wild type (n = 275) . | NOTCH1 mutated (n = 34) . | P . | |||
|---|---|---|---|---|---|---|---|
| n* . | % . | n* . | % . | n* . | % . | ||
| Age, y (range) | 69 (60-76) | 69 (60-76) | 69 (60-76) | .615 | |||
| Male | 170 | 55.0 | 152 | 55.3 | 18 | 52.9 | .797 |
| Rai stage III-IV | 34 | 11.0 | 25 | 9.1 | 9 | 26.5 | .006 |
| IGHV identity ≥ 98% | 103 | 33.3 | 77 | 28.0 | 26 | 76.5 | < .001 |
| 13q14 deletion | 160 | 51.8 | 151 | 54.9 | 9 | 26.5 | .002 |
| Normal FISH | 92 | 29.8 | 81 | 29.5 | 11 | 32.4 | .727 |
| Trisomy 12 | 61 | 19.7 | 46 | 16.7 | 15 | 44.1 | < .001 |
| 11q22-q23 deletion | 25 | 8.1 | 24 | 8.7 | 1 | 2.9 | .334 |
| 17p13 deletion | 25 | 8.1 | 24 | 8.7 | 1 | 2.9 | .334 |
| TP53 mutations | 23 | 7.4 | 21 | 7.6 | 2 | 5.9 | 1.000 |
| TP53 disruption | 33 | 10.7 | 30 | 10.9 | 3 | 8.8 | 1.000 |
| Characteristic . | All (n = 309) . | NOTCH1 wild type (n = 275) . | NOTCH1 mutated (n = 34) . | P . | |||
|---|---|---|---|---|---|---|---|
| n* . | % . | n* . | % . | n* . | % . | ||
| Age, y (range) | 69 (60-76) | 69 (60-76) | 69 (60-76) | .615 | |||
| Male | 170 | 55.0 | 152 | 55.3 | 18 | 52.9 | .797 |
| Rai stage III-IV | 34 | 11.0 | 25 | 9.1 | 9 | 26.5 | .006 |
| IGHV identity ≥ 98% | 103 | 33.3 | 77 | 28.0 | 26 | 76.5 | < .001 |
| 13q14 deletion | 160 | 51.8 | 151 | 54.9 | 9 | 26.5 | .002 |
| Normal FISH | 92 | 29.8 | 81 | 29.5 | 11 | 32.4 | .727 |
| Trisomy 12 | 61 | 19.7 | 46 | 16.7 | 15 | 44.1 | < .001 |
| 11q22-q23 deletion | 25 | 8.1 | 24 | 8.7 | 1 | 2.9 | .334 |
| 17p13 deletion | 25 | 8.1 | 24 | 8.7 | 1 | 2.9 | .334 |
| TP53 mutations | 23 | 7.4 | 21 | 7.6 | 2 | 5.9 | 1.000 |
| TP53 disruption | 33 | 10.7 | 30 | 10.9 | 3 | 8.8 | 1.000 |
Median and 25th-75th percentiles are reported for continuous variables.