Immunohistochemistry in patients with clinical, laboratory, and genetic data insufficient for a definite subclassification
| . | Clinical diagnosis . | Typical symptoms of AL . | Monoclonal gammopathy . | Positive genotyping . | Positive family history . | Successful immunohistochemistry . |
|---|---|---|---|---|---|---|
| AL suspected | 56 | 0 | 56 | 0 | 0 | 52/56 |
| ATTR suspected | 3 | 0 | 2 | 3 | 1 | 3/3 |
| Senile ATTR suspected | 7 | 0 | 0 | 0 | 0 | 6/7 |
| . | Clinical diagnosis . | Typical symptoms of AL . | Monoclonal gammopathy . | Positive genotyping . | Positive family history . | Successful immunohistochemistry . |
|---|---|---|---|---|---|---|
| AL suspected | 56 | 0 | 56 | 0 | 0 | 52/56 |
| ATTR suspected | 3 | 0 | 2 | 3 | 1 | 3/3 |
| Senile ATTR suspected | 7 | 0 | 0 | 0 | 0 | 6/7 |
Data are anamnestic, clinical, and laboratory results of the second group of 66 patients as well as immunohistochemical results.
AL suspected indicates patients who fulfilled all diagnostic criteria of AL amyloidosis but had no typical symptoms; ATTR suspected, patients with a TTR mutation and the simultaneous presence of a monoclonal gammopathy or with a new amyloidogenic mutation; and Senile ATTR suspected, patients of older age with dominant cardiac disease, in whom an amyloidogenic mutation and a monoclonal gammopathy were absent.