The 6 genes selected for genotyping in cases with MI and controls
| HGNC Gene IDa . | Description . | Microarray analysis . | Genotyping in PFCb (lowest P) . | Association with CAD, Pj,k . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ACc . | MSId . | SDe . | Ratiof . | No. SNP typedg . | rs no. of SNP . | MAFh . | Pi . | |||
| ARPC4 | Actin-related protein 2/3 complex, subunit 4, 20 kDa | −0.48 | 577 | 94 | 2.0 | 2 | rs3806667 | 0.098 | 1.70 × 10−1 | 2.6 × 10−3 |
| COMMD7 | COMM domain containing protein 7 | 0.45 | 987 | 144 | 2.2 | 10 | rs6141803 | 0.181 | 1.27 × 10−3 | ns |
| GRB2 | Growth factor receptor-bound protein 2 | −0.44 | 364 | 45 | 1.7 | 3 | rs41282071 | 0.065 | 5.56 × 10−2 | 8.3 × 10−4 |
| GTF2A2 | General transcription factor IIA, 2, 12 kDa | 0.46 | 185 | 65 | 3.7 | 17 | rs1057058 | 0.050 | 1.13 × 10−2 | ns |
| LRRFIP1 | Leucine-rich repeat (in FLII) interacting protein 1 | 0.43 | 352 | 54 | 1.9 | 4 | rs3213869 | 0.038 | 1.26 × 10−2 | 2.5 × 10−3 |
| PFKL | Phosphofructokinase, liver | −0.47 | 271 | 47 | 2.2 | 31 | rs2838551 | 0.376 | 1.27 × 10−3 | ns |
| HGNC Gene IDa . | Description . | Microarray analysis . | Genotyping in PFCb (lowest P) . | Association with CAD, Pj,k . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| ACc . | MSId . | SDe . | Ratiof . | No. SNP typedg . | rs no. of SNP . | MAFh . | Pi . | |||
| ARPC4 | Actin-related protein 2/3 complex, subunit 4, 20 kDa | −0.48 | 577 | 94 | 2.0 | 2 | rs3806667 | 0.098 | 1.70 × 10−1 | 2.6 × 10−3 |
| COMMD7 | COMM domain containing protein 7 | 0.45 | 987 | 144 | 2.2 | 10 | rs6141803 | 0.181 | 1.27 × 10−3 | ns |
| GRB2 | Growth factor receptor-bound protein 2 | −0.44 | 364 | 45 | 1.7 | 3 | rs41282071 | 0.065 | 5.56 × 10−2 | 8.3 × 10−4 |
| GTF2A2 | General transcription factor IIA, 2, 12 kDa | 0.46 | 185 | 65 | 3.7 | 17 | rs1057058 | 0.050 | 1.13 × 10−2 | ns |
| LRRFIP1 | Leucine-rich repeat (in FLII) interacting protein 1 | 0.43 | 352 | 54 | 1.9 | 4 | rs3213869 | 0.038 | 1.26 × 10−2 | 2.5 × 10−3 |
| PFKL | Phosphofructokinase, liver | −0.47 | 271 | 47 | 2.2 | 31 | rs2838551 | 0.376 | 1.27 × 10−3 | ns |
Gene identifier (ID) is by the HUGO Gene Nomenclature Committee (HGNC).
PFC, Platelet Function Cohort.
AC, average correlation r value.
MSI, mean signal intensity obtained with the 37 platelet RNA samples for the corresponding feature on the Illumina platform.
SD, standard deviation.
Ratio = maximum signal intensity/minimum signal intensity.
Number (no.) of single-nucleotide polymorphisms (SNPs) typed in the 500 DNA samples of the PFC (COMMD7 and PFKL were genotyped on a custom Illumina 1536 platform; ARPC4, GRB2, and LRRFIP1 were genotyped by Sequenom).
MAF, minor allele frequency.
Lowest P value: the association between genotype and platelet function was tested for each SNP against the 4 functional responses, and the lowest P value is presented.
Lowest P value: the association between genotype and CAD/MI in the WTCCC GWAS cohort.
In silico analysis from WTCCC CAD cases and controls; ns, not significant, and P values in bold reached the predefined level of significance.