Clinical characteristics of the DLBCL training cohort at diagnosis according to the MLH1 rs1799977 genotype
| Clinical characteristic . | MLH1 rs1799977 . | P . | |
|---|---|---|---|
| AA . | AG/GG . | ||
| Age > 60 y | 71/111 (64.0%) | 33/52 (63.5%) | .950 |
| Male | 59/111 (53.2%) | 33/52 (63.5%) | .216 |
| ECOG PS > 1 | 13/111 (11.7%) | 8/52 (15.4%) | .514 |
| Charlson Comorbidity Index | 1 (0-2) | 1 (0-3) | .115 |
| Ann Arbor stage III or IV | 56/111 (50.5%) | 29/52 (55.8%) | .526 |
| B symptoms | 21/111 (18.9%) | 17/52 (32.7%) | .052 |
| Bulky | 30/111 (27.0%) | 16/52 (30.8%) | .620 |
| Extranodal sites > 1 | 28/111 (25.2%) | 13/52 (25.0%) | .975 |
| LDH > ULN | 33/111 (29.7%) | 21/52 (40.4%) | .177 |
| IPI 3-5 | 32/111 (28.8%) | 17/52 (32.7%) | .616 |
| Non-GC phenotype | 35/79 (44.3%) | 18/48 (37.5%) | .450 |
| RDI of doxorubicin, % | 94.8 (81.8-100) | 88.2 (76.1-99.8) | .123 |
| RDI of cyclophosphamide, % | 95.8 (87.5-100) | 92.1 (80.7-100) | .236 |
| No. of R-CHOP courses | 6 (6-8) | 6 (4-8) | .372 |
| 1-year treatment-related mortality | 1.8% | 6.0% | .286 |
| Clinical characteristic . | MLH1 rs1799977 . | P . | |
|---|---|---|---|
| AA . | AG/GG . | ||
| Age > 60 y | 71/111 (64.0%) | 33/52 (63.5%) | .950 |
| Male | 59/111 (53.2%) | 33/52 (63.5%) | .216 |
| ECOG PS > 1 | 13/111 (11.7%) | 8/52 (15.4%) | .514 |
| Charlson Comorbidity Index | 1 (0-2) | 1 (0-3) | .115 |
| Ann Arbor stage III or IV | 56/111 (50.5%) | 29/52 (55.8%) | .526 |
| B symptoms | 21/111 (18.9%) | 17/52 (32.7%) | .052 |
| Bulky | 30/111 (27.0%) | 16/52 (30.8%) | .620 |
| Extranodal sites > 1 | 28/111 (25.2%) | 13/52 (25.0%) | .975 |
| LDH > ULN | 33/111 (29.7%) | 21/52 (40.4%) | .177 |
| IPI 3-5 | 32/111 (28.8%) | 17/52 (32.7%) | .616 |
| Non-GC phenotype | 35/79 (44.3%) | 18/48 (37.5%) | .450 |
| RDI of doxorubicin, % | 94.8 (81.8-100) | 88.2 (76.1-99.8) | .123 |
| RDI of cyclophosphamide, % | 95.8 (87.5-100) | 92.1 (80.7-100) | .236 |
| No. of R-CHOP courses | 6 (6-8) | 6 (4-8) | .372 |
| 1-year treatment-related mortality | 1.8% | 6.0% | .286 |
The 25th to 75th percentiles are reported in parentheses for continuous variables.
GC indicates germinal center.