Features of AMLs induced by Flt3+/+ or Flt3−/− BM infected by Hoxa9/Meis1 or Hoxa9 alone
| . | Survival, d . | WBC, ×109/L . | PLT, ×109/L . | Spleen weight, mg . |
|---|---|---|---|---|
| Flt3+/+Hoxa9/Meis1 | 39 ± 7 | 235 ± 144* | 283 ± 102 | 307 ± 127 |
| Flt3−/−Hoxa9/Meis1 | 40 ± 15 | 106 ± 36* | 231 ± 87 | 268 ± 121 |
| Flt3+/+Hoxa9 | 177 ± 32 | 91 ± 132 | 234 ± 48 | 494 ± 207 |
| Flt3−/−Hoxa9 | 150 ± 18 | 63 ± 42 | 262 ± 274 | 392 ± 128 |
| . | Survival, d . | WBC, ×109/L . | PLT, ×109/L . | Spleen weight, mg . |
|---|---|---|---|---|
| Flt3+/+Hoxa9/Meis1 | 39 ± 7 | 235 ± 144* | 283 ± 102 | 307 ± 127 |
| Flt3−/−Hoxa9/Meis1 | 40 ± 15 | 106 ± 36* | 231 ± 87 | 268 ± 121 |
| Flt3+/+Hoxa9 | 177 ± 32 | 91 ± 132 | 234 ± 48 | 494 ± 207 |
| Flt3−/−Hoxa9 | 150 ± 18 | 63 ± 42 | 262 ± 274 | 392 ± 128 |
Values shown are mean ± SD.
WBC indicates white blood cell count; and PLT, platelet count.
The incidence of Flt3 genotype on leukocytosis could not be confirmed by comparing the WBC of secondary recipients that received Flt3−/− and Flt3+/+Hoxa9/Meis1 (data not shown).