Table 1 HLA class I serologically... | American Society of Hematology

Table 1

HLA class I serologically defined cross-reactive groups (CREGs) based on the Rodey scheme and example of the evaluation of minor versus major mismatches in a donor (HLA-A1,24, HLA-B8,35)-recipient (HLA-A1,28, HLA-B8,35) pair

CREG*	Antigen specificities included	CREG present†		CREG match status‡
CREG*	Antigen specificities included	Donor	Recipient	CREG match status‡
1C	A1, 3, 9 (23, 24), 11, 29, 30, 31, 36, 80	+	+	Match
10C	A10 (25, 26, 34, 66), 11, 28 (68, 69), 32, 33, 43, 74	−	+	Major mismatch in GvHD direction
2C	A2, 9 (23, 24), 28 (68, 69), B17 (57, 58)	+	+	Match
5C	B5 (51, 52), 15 (62, 63, 75, 76, 77), 17 (57, 58), 18, 21 (49, 50), 35, 46, 53, 70 (71, 72), 73, 78	+	+	Match
7C	B7, 8, 13, 22 (54, 55, 56), 27, 40 (60, 61), 41, 42, 47, 48, 59, 67, 81, 82	+	+	Match
8C	B8, 14 (64, 65), 16 (38, 39), 18, 59, 67	+	+	Match
12C	B12 (44, 45), 13, 21 (49, 50), 37, 40 (60, 61), 41, 47	−	−	Match
Bw4	A23, 24, 25, 32, B13, 27, 37, 38, 44, 47, 49, 51, 52, 53, 57, 58, 59, 63, 77	+	−	Major mismatch in engraftment direction
Bw6	B7, 8, 18, 35, 39, 41, 42, 45, 46, 48, 50, 54, 55, 56, 60, 61, 62, 64, 65, 67, 71, 72, 73, 75, 76, 78, 81, 82	+	+	Match

CREG*	Antigen specificities included	CREG present†		CREG match status‡
CREG*	Antigen specificities included	Donor	Recipient	CREG match status‡
1C	A1, 3, 9 (23, 24), 11, 29, 30, 31, 36, 80	+	+	Match
10C	A10 (25, 26, 34, 66), 11, 28 (68, 69), 32, 33, 43, 74	−	+	Major mismatch in GvHD direction
2C	A2, 9 (23, 24), 28 (68, 69), B17 (57, 58)	+	+	Match
5C	B5 (51, 52), 15 (62, 63, 75, 76, 77), 17 (57, 58), 18, 21 (49, 50), 35, 46, 53, 70 (71, 72), 73, 78	+	+	Match
7C	B7, 8, 13, 22 (54, 55, 56), 27, 40 (60, 61), 41, 42, 47, 48, 59, 67, 81, 82	+	+	Match
8C	B8, 14 (64, 65), 16 (38, 39), 18, 59, 67	+	+	Match
12C	B12 (44, 45), 13, 21 (49, 50), 37, 40 (60, 61), 41, 47	−	−	Match
Bw4	A23, 24, 25, 32, B13, 27, 37, 38, 44, 47, 49, 51, 52, 53, 57, 58, 59, 63, 77	+	−	Major mismatch in engraftment direction
Bw6	B7, 8, 18, 35, 39, 41, 42, 45, 46, 48, 50, 54, 55, 56, 60, 61, 62, 64, 65, 67, 71, 72, 73, 75, 76, 78, 81, 82	+	+	Match

As defined by Rodey² and Rodey et al.³

†

Based on the HLA typing of the donor and recipient in the table title, these columns indicate whether the 9 CREG groups shown in the first column are present (+) or absent (−) in the donor or recipient.

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