Binding sites for transcription factors with altered binding activity in the promoters of SOD2-down-regulated genes
| Transcription factor module . | Genes containing modules . |
|---|---|
| ETS_AP1 | ALOX12B, APEG1, CTBP2, GLYCTK, INHBE, JDP2, MARK1, MONDOA, MYH16, NXF2, PRRX1, RDH12, SAC, SLC19A2, SORT1, SLIT1, STAB2, TMC, TULP2, WDTC2, ZNF526 |
| ETS_sp1 | ALOX12b, APEG1, BCAS4, CTBP2, GLCTK, SPR146, GSN, HRMT1L4, INPP1, IQCE, JDP2, KCNN2, KLK12, MOGAT1, MONDOA, NXF2, PRRX1, SLC19A2, SMPD1, TMC1, TRIM14, TPRM8, TULP2, WDTC2 |
| STAT_ETS | ACPP, GSN, KLK12, MARK1, NXF2, SMPD1, SORT1, STAB2, TMC1, TRIM14, WDTC2 |
| ETS_CEBP | APEG1, CTBP2, HRMT1L4 |
| AP1_ETS_EGRF | ALOX12B, APEG1, ASB4, GSN, JDP2, KLK12, MARK1, MOGAT1, SAC, SMPD1, WDTC2 |
| EGR_SP1 | ALOX12B, APEG1, BCAS4, COLEC12, CTBP2, GYCTK, GSN, HRMT1L4, INHBE, ANPP1, KCNN2, MONDOA, SLIT1, SMPD1, TRIM14, TRPM8, WDTC2, ZNF526 |
| EGR_NFAT | ASAH3, GSN, GZMK, HRMT1L4, ICOS, JDP2, KNG1, SAC, SLIT1, TRPM8, WDTC2 |
| CREB_NFAT_NFAT | CAPZA3, CZMK, MONDOA, TMC1 |
| EKLF_SP1 | CTBP2, JDP2 |
| Transcription factor module . | Genes containing modules . |
|---|---|
| ETS_AP1 | ALOX12B, APEG1, CTBP2, GLYCTK, INHBE, JDP2, MARK1, MONDOA, MYH16, NXF2, PRRX1, RDH12, SAC, SLC19A2, SORT1, SLIT1, STAB2, TMC, TULP2, WDTC2, ZNF526 |
| ETS_sp1 | ALOX12b, APEG1, BCAS4, CTBP2, GLCTK, SPR146, GSN, HRMT1L4, INPP1, IQCE, JDP2, KCNN2, KLK12, MOGAT1, MONDOA, NXF2, PRRX1, SLC19A2, SMPD1, TMC1, TRIM14, TPRM8, TULP2, WDTC2 |
| STAT_ETS | ACPP, GSN, KLK12, MARK1, NXF2, SMPD1, SORT1, STAB2, TMC1, TRIM14, WDTC2 |
| ETS_CEBP | APEG1, CTBP2, HRMT1L4 |
| AP1_ETS_EGRF | ALOX12B, APEG1, ASB4, GSN, JDP2, KLK12, MARK1, MOGAT1, SAC, SMPD1, WDTC2 |
| EGR_SP1 | ALOX12B, APEG1, BCAS4, COLEC12, CTBP2, GYCTK, GSN, HRMT1L4, INHBE, ANPP1, KCNN2, MONDOA, SLIT1, SMPD1, TRIM14, TRPM8, WDTC2, ZNF526 |
| EGR_NFAT | ASAH3, GSN, GZMK, HRMT1L4, ICOS, JDP2, KNG1, SAC, SLIT1, TRPM8, WDTC2 |
| CREB_NFAT_NFAT | CAPZA3, CZMK, MONDOA, TMC1 |
| EKLF_SP1 | CTBP2, JDP2 |
Using Genomatix's Gene2Promoter software, we identifed the known and predicted promoters of 42 of 49 SOD2 down-regulated genes identified in Figure 5A. Using Genomatix's ModelInspector, we searched for promoter modules contained within the promoters. This is a summarized list of the promoter modules identified. A detailed listing of the identified modules and the locations is provided in Table S2.