Table 3 Multicovariate analysis of... | American Society of Hematology

Table 3

Multicovariate analysis of 92714C>G (D1241E) and FVIII:C levels in the GAIT population

Covariate*	Model 1		Model 2		Model 3		Model 4
Covariate*	β†	P‡	β†	P‡	β†	P‡	β†	P‡
Age, y	−4.12	.089	−3.43	.178	−3.75	.065	−3.33	.090
Sex	4.43	.364	6.45	.187	13.72	.001	13.41	.001
Age × sex	−1.33	.729	−4.93	.250	−3.37	.322	−3.73	.257
A15§	3.62	.152	3.00	.258	3.44	.102	3.03	.136
A15 × sex	2.12	.596	5.62	.206	3.88	.272	4.14	.225
A50§	3.48	< .001	3.13	< .001	1.44	.013	1.58	.005
A50 × sex	−2.78	.004	−2.30	.015	−1.48	.058	−1.42	.059
OC status‖	−23.82	.056	−23.80	.080	−11.22	.298	−15.10	.148
Smoking status‖	−11.45	.021	−13.48	.008	−5.84	.153	−8.27	.038
AA¶	25.85	.002	27.61	.001	10.36	.135	11.47	.084
AB¶	26.03	.109	35.41	.047	11.23	.444	9.91	.482
AO¶	21.80	< .001	15.78	.006	3.75	.447	2.71	.568
BO¶	26.91	.002	29.53	.001	15.56	.032	16.97	.015
DM status‖	−6.11	.618	−25.36	.101	−4.01	.746	−9.45	.470
Fibrinogen level, IU dL⁻¹	13.56	< .001	9.17	.012	2.55	.400	0.37	.901
BMI, kg m⁻²	0.22	.718	−0.46	.471	0.85	.085	−0.05	.926
VLDL level, mM	45.58	< .001	22.49	.082	21.12	.039	8.60	.398
FIX:C level, IU dL⁻¹	N/A	N/A	0.56	< .001	N/A	N/A	0.45	< .001
VWF:Ag level, IU dL⁻¹	N/A	N/A	N/A	N/A	0.73	< .001	0.66	< .001
D1241E#	14.33	.016	11.99	.049	7.26	.142	6.10	.199

Covariate*	Model 1		Model 2		Model 3		Model 4
Covariate*	β†	P‡	β†	P‡	β†	P‡	β†	P‡
Age, y	−4.12	.089	−3.43	.178	−3.75	.065	−3.33	.090
Sex	4.43	.364	6.45	.187	13.72	.001	13.41	.001
Age × sex	−1.33	.729	−4.93	.250	−3.37	.322	−3.73	.257
A15§	3.62	.152	3.00	.258	3.44	.102	3.03	.136
A15 × sex	2.12	.596	5.62	.206	3.88	.272	4.14	.225
A50§	3.48	< .001	3.13	< .001	1.44	.013	1.58	.005
A50 × sex	−2.78	.004	−2.30	.015	−1.48	.058	−1.42	.059
OC status‖	−23.82	.056	−23.80	.080	−11.22	.298	−15.10	.148
Smoking status‖	−11.45	.021	−13.48	.008	−5.84	.153	−8.27	.038
AA¶	25.85	.002	27.61	.001	10.36	.135	11.47	.084
AB¶	26.03	.109	35.41	.047	11.23	.444	9.91	.482
AO¶	21.80	< .001	15.78	.006	3.75	.447	2.71	.568
BO¶	26.91	.002	29.53	.001	15.56	.032	16.97	.015
DM status‖	−6.11	.618	−25.36	.101	−4.01	.746	−9.45	.470
Fibrinogen level, IU dL⁻¹	13.56	< .001	9.17	.012	2.55	.400	0.37	.901
BMI, kg m⁻²	0.22	.718	−0.46	.471	0.85	.085	−0.05	.926
VLDL level, mM	45.58	< .001	22.49	.082	21.12	.039	8.60	.398
FIX:C level, IU dL⁻¹	N/A	N/A	0.56	< .001	N/A	N/A	0.45	< .001
VWF:Ag level, IU dL⁻¹	N/A	N/A	N/A	N/A	0.73	< .001	0.66	< .001
D1241E#	14.33	.016	11.99	.049	7.26	.142	6.10	.199

For model 1, n = 361; for model 2, n = 313; for model 3, n = 307; for model 4, n = 306.

Endogenous, environmental, and genetic variables included in the marginal measured-genotype association analysis of the relationship between D1241E and FVIII:C levels in GAIT.

†

The estimated effect (β) of a given covariate or each D-allele of the FVIII D1241E polymorphism (F8 92714C>G) on FVIII:C levels.

‡

The P value for each β.

The coefficient for splines with knots at 15 and 50 years.

‖

Status (yes/no) indicates either any use (smoking and oral contraception) or the presence of diagnostic criteria for DM.

The 4 ABO genotypes, other than OO (reference genotype), found in GAIT subjects.

D1241E genotypes were grouped and represented with indicator variables as follows: 1 (D/D and D/Y); 0 (D/d); and −1 (d/d and d/Y).

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