Determinants associated with ESLD in patients with chronic hepatitis C
| . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age at infection, per 10 y | 1.8 (1.6-2.1) | < .001 |
| HCV genotype | .06 | |
| Type 2-5 | 1.0 | |
| Type 1 | 1.9 (1.0-3.6) | |
| History of alcohol abuse | .01 | |
| No | 1.0 | |
| Yes | 2.5 (1.3-4.7) | |
| HIV status | < .001 | |
| Negative | 1.0 | |
| Positive | 5.5 (3.3-9.3) | |
| HAART* | .37 | |
| No | 1.0 | |
| Yes | 0.8 (0.5-1.3) | |
| Multivariate analysis | ||
| Age at infection, per 10 y | 2.3 (2.0-2.8) | < .001 |
| HCV genotype | .02 | |
| Type 2-5 | 1.0 | |
| Type 1 | 2.2 (1.1-4.2) | |
| History of alcohol abuse | < .001 | |
| No | 1.0 | |
| Yes | 4.9 (2.5-9.6) | |
| HIV status | < .001 | |
| Negative | 1.0 | |
| Positive | 13.8 (7.5-25.3) | |
| . | Hazard ratio (95% CI) . | P . |
|---|---|---|
| Univariate analysis | ||
| Age at infection, per 10 y | 1.8 (1.6-2.1) | < .001 |
| HCV genotype | .06 | |
| Type 2-5 | 1.0 | |
| Type 1 | 1.9 (1.0-3.6) | |
| History of alcohol abuse | .01 | |
| No | 1.0 | |
| Yes | 2.5 (1.3-4.7) | |
| HIV status | < .001 | |
| Negative | 1.0 | |
| Positive | 5.5 (3.3-9.3) | |
| HAART* | .37 | |
| No | 1.0 | |
| Yes | 0.8 (0.5-1.3) | |
| Multivariate analysis | ||
| Age at infection, per 10 y | 2.3 (2.0-2.8) | < .001 |
| HCV genotype | .02 | |
| Type 2-5 | 1.0 | |
| Type 1 | 2.2 (1.1-4.2) | |
| History of alcohol abuse | < .001 | |
| No | 1.0 | |
| Yes | 4.9 (2.5-9.6) | |
| HIV status | < .001 | |
| Negative | 1.0 | |
| Positive | 13.8 (7.5-25.3) | |
Use of HAART was evaluated in HIV+ patients and considered as a time-dependant variable.