Results of logistic regression analysis on XPD haplotypes and selected toxicity categories
| XPD haplotype . | Patients . | Liver toxicity . | Lung toxicity . | Metabolic toxicity . | GU toxicity . | GI Toxicity . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | % . | OR . | 95% CI . | OR . | 95% CI . | OR . | 95% CI . | OR . | 95% CI . | OR . | 95% CI . | |
| AA* | 72 | 37.70 | 1 | NA | 1 | NA | 1 | NA | 1 | NA | 1 | NA |
| DA | 22 | 11.52 | 2.44 | 0.82-9.07 | 0.94 | 0.34-2.88 | 3.60 | 0.93-23.8 | 1.00 | 0.27-4.77 | 1.04 | 0.42-2.57 |
| DC | 54 | 28.27 | 1.60 | 0.75-3.55 | 0.55 | 0.26-1.16 | 1.56 | 0.66-3.94 | 0.84 | 0.31-2.37 | 0.45 | 0.23-0.85 |
| Other | 43 | 22.51 | 0.93 | 0.43-2.05 | 0.98 | 0.42-2.35 | 1.28 | 0.53-3.25 | 0.42 | 0.16-1.09 | 0.99 | 0.48-2.04 |
| AA/AC/BB/BC* | 102 | 46.60 | 1 | NA | 1 | NA | 1 | NA | 1 | NA | 1 | NA |
| DA/DB/DC | 89 | 53.40 | 2.00 | 1.08-3.82 | 0.72 | 0.39-1.33 | 1.69 | 0.83-3.56 | 1.33 | 0.62-2.92 | 0.66 | 0.39-1.12 |
| XPD haplotype . | Patients . | Liver toxicity . | Lung toxicity . | Metabolic toxicity . | GU toxicity . | GI Toxicity . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | % . | OR . | 95% CI . | OR . | 95% CI . | OR . | 95% CI . | OR . | 95% CI . | OR . | 95% CI . | |
| AA* | 72 | 37.70 | 1 | NA | 1 | NA | 1 | NA | 1 | NA | 1 | NA |
| DA | 22 | 11.52 | 2.44 | 0.82-9.07 | 0.94 | 0.34-2.88 | 3.60 | 0.93-23.8 | 1.00 | 0.27-4.77 | 1.04 | 0.42-2.57 |
| DC | 54 | 28.27 | 1.60 | 0.75-3.55 | 0.55 | 0.26-1.16 | 1.56 | 0.66-3.94 | 0.84 | 0.31-2.37 | 0.45 | 0.23-0.85 |
| Other | 43 | 22.51 | 0.93 | 0.43-2.05 | 0.98 | 0.42-2.35 | 1.28 | 0.53-3.25 | 0.42 | 0.16-1.09 | 0.99 | 0.48-2.04 |
| AA/AC/BB/BC* | 102 | 46.60 | 1 | NA | 1 | NA | 1 | NA | 1 | NA | 1 | NA |
| DA/DB/DC | 89 | 53.40 | 2.00 | 1.08-3.82 | 0.72 | 0.39-1.33 | 1.69 | 0.83-3.56 | 1.33 | 0.62-2.92 | 0.66 | 0.39-1.12 |
NA indicates not applicable.
*Referent haplotype or haplotype category.