Distribution of patients' DNA repair genotypes/haplotypes by AML onset
| Gene polymorphism . | P† . | AML onset . | . | |
|---|---|---|---|---|
| De novo . | Secondary . | Overall no. (%) . | ||
| APE1 Asp148Glu | .51 | |||
| GG* | 43 | 9 | 52 (29.21) | |
| GT | 54 | 19 | 73 (41.01) | |
| TT | 42 | 11 | 53 (29.78) | |
| XRCC1 Arg399Gln | .54 | |||
| GG | 73 | 18 | 91 (46.91) | |
| GA | 68 | 19 | 87 (44.85) | |
| AA | 11 | 5 | 16 (8.25) | |
| XRCC3 Thr241Met | .31 | |||
| CC | 71 | 23 | 94 (50.81) | |
| CT | 59 | 16 | 75 (40.54) | |
| TT | 15 | 1 | 16 (8.65) | |
| ERCC1 IVS5+34C>A | .58 | |||
| CC | 119 | 30 | 149 (74.87) | |
| CA | 34 | 12 | 46 (23.12) | |
| AA | 3 | 1 | 4 (2.01) | |
| XPD Lys751Gln | .18 | |||
| AA | 63 | 23 | 86 (43.65) | |
| AC | 71 | 13 | 84 (42.64) | |
| CC | 20 | 7 | 27 (13.71) | |
| XPD Asp312Asn | .75 | |||
| GG | 74 | 21 | 95 (49.22) | |
| GA | 64 | 15 | 79 (40.93) | |
| AA | 14 | 5 | 19 (9.84) | |
| XPD haplotype* | .60 | |||
| AA | 54 | 18 | 72 (37.70) | |
| AC | 7 | 4 | 11 (5.76) | |
| BB | 9 | 4 | 13 (6.81) | |
| BC | 5 | 1 | 6 (3.14) | |
| DA | 19 | 3 | 22 (11.52) | |
| DB | 11 | 2 | 13 (6.81) | |
| DC | 45 | 9 | 54 (28.27) | |
| Gene polymorphism . | P† . | AML onset . | . | |
|---|---|---|---|---|
| De novo . | Secondary . | Overall no. (%) . | ||
| APE1 Asp148Glu | .51 | |||
| GG* | 43 | 9 | 52 (29.21) | |
| GT | 54 | 19 | 73 (41.01) | |
| TT | 42 | 11 | 53 (29.78) | |
| XRCC1 Arg399Gln | .54 | |||
| GG | 73 | 18 | 91 (46.91) | |
| GA | 68 | 19 | 87 (44.85) | |
| AA | 11 | 5 | 16 (8.25) | |
| XRCC3 Thr241Met | .31 | |||
| CC | 71 | 23 | 94 (50.81) | |
| CT | 59 | 16 | 75 (40.54) | |
| TT | 15 | 1 | 16 (8.65) | |
| ERCC1 IVS5+34C>A | .58 | |||
| CC | 119 | 30 | 149 (74.87) | |
| CA | 34 | 12 | 46 (23.12) | |
| AA | 3 | 1 | 4 (2.01) | |
| XPD Lys751Gln | .18 | |||
| AA | 63 | 23 | 86 (43.65) | |
| AC | 71 | 13 | 84 (42.64) | |
| CC | 20 | 7 | 27 (13.71) | |
| XPD Asp312Asn | .75 | |||
| GG | 74 | 21 | 95 (49.22) | |
| GA | 64 | 15 | 79 (40.93) | |
| AA | 14 | 5 | 19 (9.84) | |
| XPD haplotype* | .60 | |||
| AA | 54 | 18 | 72 (37.70) | |
| AC | 7 | 4 | 11 (5.76) | |
| BB | 9 | 4 | 13 (6.81) | |
| BC | 5 | 1 | 6 (3.14) | |
| DA | 19 | 3 | 22 (11.52) | |
| DB | 11 | 2 | 13 (6.81) | |
| DC | 45 | 9 | 54 (28.27) | |
GG genotype is the most common among whites (data obtained through NCBI SNP database).
*Haplotypes: A, Lys751A/Asp312G; B, Gln751C/Asn312A; C, Lys751A/Asn312A; D, Gln751C/Asp312G. Haplotype frequencies: A, 0.463; B, 0.117; C, 0.186; D, 0.233.
†P values are for comparison of de novo and secondary AML onset values.