Summary of previous publications reporting associations with candidate genes that meet the P < .05 threshold in the current validation study
| Gene . | Reference . | Phenotype . | Genome . | Donor type . | SNP . | Alleles* . | MAF . | HR . | Unadjusted CI . | P . |
|---|---|---|---|---|---|---|---|---|---|---|
| IL2 | MacMillan et al17 | II-IV | PT | URD | rs2069762 | G/T | 0.3 | 2.1 | (1.0-4.5) | .05 |
| IL6 | Mullighan et al10 | I-IV | DNR | MRD | rs1800795 | G/C | 0.4 | 4.4 | (1.6-11.7) | .001 |
| IL6 | Karabon e tal18 | II-IV | DNR | NR | rs1800795 | G/C | 0.5 | 3.4 | (1.1-13.0) | .03 |
| IL6 | Ambruzova et al19 | II-IV | PT | Allo | rs1800795 | G/C | 0.5 | 2.2 | (1.1-4.4) | .03 |
| IL10 | Lin et al1 | III-IV | PT | MRD | rs1800871† | A/C | 0.3 | |||
| IL10 | Lin et al1 | III-IV | PT | MRD | rs1800872 | A/C | 0.3 | 0.4 | (0.2-0.9) | .02 |
| CTLA4 | Perez-Garcia et al8 | II-IV | DNR | MRD | rs3087243 | A/G | 0.5 | 1.5 | (1.0-2.3) | .03 |
| HPSE | Ostrovsky et al12 | II-IV and III-IV | PT | Allo | rs4364254 | T/C | 0.4 | NR | NR | < .01 |
| MTHFR | Robien et al30 | I-IV | PT | Allo | rs1801131 | A/C | 0.4 | 3.6 | (1.0-12.7) | < .01 |
| Gene . | Reference . | Phenotype . | Genome . | Donor type . | SNP . | Alleles* . | MAF . | HR . | Unadjusted CI . | P . |
|---|---|---|---|---|---|---|---|---|---|---|
| IL2 | MacMillan et al17 | II-IV | PT | URD | rs2069762 | G/T | 0.3 | 2.1 | (1.0-4.5) | .05 |
| IL6 | Mullighan et al10 | I-IV | DNR | MRD | rs1800795 | G/C | 0.4 | 4.4 | (1.6-11.7) | .001 |
| IL6 | Karabon e tal18 | II-IV | DNR | NR | rs1800795 | G/C | 0.5 | 3.4 | (1.1-13.0) | .03 |
| IL6 | Ambruzova et al19 | II-IV | PT | Allo | rs1800795 | G/C | 0.5 | 2.2 | (1.1-4.4) | .03 |
| IL10 | Lin et al1 | III-IV | PT | MRD | rs1800871† | A/C | 0.3 | |||
| IL10 | Lin et al1 | III-IV | PT | MRD | rs1800872 | A/C | 0.3 | 0.4 | (0.2-0.9) | .02 |
| CTLA4 | Perez-Garcia et al8 | II-IV | DNR | MRD | rs3087243 | A/G | 0.5 | 1.5 | (1.0-2.3) | .03 |
| HPSE | Ostrovsky et al12 | II-IV and III-IV | PT | Allo | rs4364254 | T/C | 0.4 | NR | NR | < .01 |
| MTHFR | Robien et al30 | I-IV | PT | Allo | rs1801131 | A/C | 0.4 | 3.6 | (1.0-12.7) | < .01 |
Allo indicates allogeneic; CI, confidence interval; DNR, donor; HR, hazard ratio; MAF, minor allele frequency; MRD, matched related donor; NR, not reported; PT, patient; SNP, single-nucleotide polymorphism; and URD, unrelated donor.
The first allele is designated as the minor allele, and the second allele is designated as the major allele.
Assessed as component of a haplotype.