Doses and composition of T-cell infusions
Patient no. . | First dose, TNC/106/kg . | CD8+/106/kg . | % CD8+ . | Vitality, % . | Second dose, TNC/106/kg . | CD8+/106/kg . | % CD8+ . | Vitality, % . | Third dose, TNC/106/kg . | CD8+/106/kg . | % CD8+ . | Vitality, % . |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 0.1 | 0.06 | 59 | NT | 0.08 | 0.06 | 72 | 100 | 1.48 | 1.1 | 76 | 100 |
2 | 0.6 | 0.5 | 82 | 98 | 1.2 | 1.0 | 84 | NT | NA | — | — | — |
3 | 2.4 | 1.3 | 52 | 100 | 1.2 | 1.2 | 98 | 99 | 1.4 | 1.3 | 83 | 99 |
4 | 3.9 | 3.1 | 80 | 98 | 7.1 | 5.7 | 79 | 93 | 1.3 | 1.2 | 80 | 99 |
5 | 4.4 | 4.1 | 94 | 98 | 2.5 | 1.3 | 51 | 90 | 7.6 | 6.6 | 87 | 97 |
6 | 5.0 | 3.6 | 72 | 99 | 5.4 | 3.4 | 63 | 96 | 6.9 | 5 | 72 | 95 |
7 | 5.0 | 3.9 | 79 | 100 | 2.7 | 1.9 | 72 | 94 | 11 | 9.5 | 85 | 98 |
8 | 3.0 | 1.8 | 67 | 90 | 2.0 | 1.6 | 81 | 97 | 1.9 | 1.5 | 80 | 96 |
9 | 5.5 | 3.2 | 59 | 98 | 3.2 | 1.6 | 50 | 97 | 2.9 | 2.4 | 84 | 90 |
10 | 1.1 | 0.9 | 83 | 99 | NA | — | — | — | NA | — | — | — |
11 | 4.0 | 3.3 | 82 | 98 | 2.7 | 2.3 | 85 | 90 | 4.1 | 3.4 | 83 | 90 |
12 | 2.1 | 1.1 | 69 | 96 | 3.0 | 2.5 | 81 | 90 | 6.1 | 5.7 | 90 | 98 |
13 | 3.0 | 1.9 | 62 | 98 | 4.4 | 3.6 | 83 | NT | 3.7 | 2.6 | 72 | 98 |
14 | 1.0 | 0.8 | 81 | 90 | 2.0 | 1.7 | 74 | 91 | 1.9 | 1.5 | 79 | 90 |
Patient no. . | First dose, TNC/106/kg . | CD8+/106/kg . | % CD8+ . | Vitality, % . | Second dose, TNC/106/kg . | CD8+/106/kg . | % CD8+ . | Vitality, % . | Third dose, TNC/106/kg . | CD8+/106/kg . | % CD8+ . | Vitality, % . |
---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | 0.1 | 0.06 | 59 | NT | 0.08 | 0.06 | 72 | 100 | 1.48 | 1.1 | 76 | 100 |
2 | 0.6 | 0.5 | 82 | 98 | 1.2 | 1.0 | 84 | NT | NA | — | — | — |
3 | 2.4 | 1.3 | 52 | 100 | 1.2 | 1.2 | 98 | 99 | 1.4 | 1.3 | 83 | 99 |
4 | 3.9 | 3.1 | 80 | 98 | 7.1 | 5.7 | 79 | 93 | 1.3 | 1.2 | 80 | 99 |
5 | 4.4 | 4.1 | 94 | 98 | 2.5 | 1.3 | 51 | 90 | 7.6 | 6.6 | 87 | 97 |
6 | 5.0 | 3.6 | 72 | 99 | 5.4 | 3.4 | 63 | 96 | 6.9 | 5 | 72 | 95 |
7 | 5.0 | 3.9 | 79 | 100 | 2.7 | 1.9 | 72 | 94 | 11 | 9.5 | 85 | 98 |
8 | 3.0 | 1.8 | 67 | 90 | 2.0 | 1.6 | 81 | 97 | 1.9 | 1.5 | 80 | 96 |
9 | 5.5 | 3.2 | 59 | 98 | 3.2 | 1.6 | 50 | 97 | 2.9 | 2.4 | 84 | 90 |
10 | 1.1 | 0.9 | 83 | 99 | NA | — | — | — | NA | — | — | — |
11 | 4.0 | 3.3 | 82 | 98 | 2.7 | 2.3 | 85 | 90 | 4.1 | 3.4 | 83 | 90 |
12 | 2.1 | 1.1 | 69 | 96 | 3.0 | 2.5 | 81 | 90 | 6.1 | 5.7 | 90 | 98 |
13 | 3.0 | 1.9 | 62 | 98 | 4.4 | 3.6 | 83 | NT | 3.7 | 2.6 | 72 | 98 |
14 | 1.0 | 0.8 | 81 | 90 | 2.0 | 1.7 | 74 | 91 | 1.9 | 1.5 | 79 | 90 |
NT indicates not tested; NA, not administered; and —, not applicable.