Table 1 The effect of IgG1 versus IgG2a... | American Society of Hematology

Table 1

The effect of IgG1 versus IgG2a anti-CD20 pretreatment on the induction of Tregs in FoxP3-GFP/FVIII^−/− mice

Treatment	Total splenocytes, × 10⁶	Ratio of CD4⁺ T cells, %	Ratio of Tregs, % of CD4⁺ T cells	Total Tregs in the spleen, × 10⁵
Nontreated naive mice	38.9 ± 6.2	19.4 ± 2.0	12.4 ± 0.4	8.4 ± 0.7
IgG1 anti-CD20 + FVIII	27.7 ± 2.8*	31.4 ± 1.3*	13.0 ± 0.3†	11.1 ± 1.0*
IgG2a anti-CD20 + FVIII	22.7 ± 2.2*	37.2 ± 2.7*	12.5 ± 0.8†	10.1 ± 0.8†

Treatment	Total splenocytes, × 10⁶	Ratio of CD4⁺ T cells, %	Ratio of Tregs, % of CD4⁺ T cells	Total Tregs in the spleen, × 10⁵
Nontreated naive mice	38.9 ± 6.2	19.4 ± 2.0	12.4 ± 0.4	8.4 ± 0.7
IgG1 anti-CD20 + FVIII	27.7 ± 2.8*	31.4 ± 1.3*	13.0 ± 0.3†	11.1 ± 1.0*
IgG2a anti-CD20 + FVIII	22.7 ± 2.2*	37.2 ± 2.7*	12.5 ± 0.8†	10.1 ± 0.8†

P < .05, compared with nontreated naive mice (Student t test).

Not significant, compared with nontreated naive mice.