Table 3 B-cell subpopulations and... | American Society of Hematology

Table 3

B-cell subpopulations and clinical characteristics

Parameter	Scleroderma			Bronchiolitis obliteraus			Mild/moderate vs severe			≤ 2 vs > 2 organs involved
Parameter	Yes	No	P	Yes	No	P	Mild/moderate	Severe	P	≤ 2	> 2	P
CD19⁺ B cells × 10⁶/L	302	453	.06	258	428	.041*	420	207	.07	405	227	.019*
Immature B cells absolute × 10⁶/L	26	28	.74	25	28	.57	26	26	.7	31	23	.8
%	14.1	7.7	.02*	16.1	8.04	.002*	9.2	14.5	.54	9.2	5.7	.07
Transitional B cells absolute × 10⁶/L	26	23	.78	11	23	.25	19	18	.6	22	15	.3
%	7.2	4.1	.18	4	6.2	.38	7.2	7	.48	6.1	3.6	.15
Naive B cells absolute × 10⁶/L	270	380	.2	200	360	.05	360	170	.07	340	170	.03*
%	84	84	.9	77	85	.0089*	86	79	.012*	85	83	.58
Class-switched memory B cells absolute × 10⁶/L	10	40	.005*	25	30	.6	26	11	.44	30	10	.038*
%	6.1	8	.28	9	7.6	.41	6.3	7.8	.03*	6.3	7.9	.55
Non–class-switched memory B cells absolute × 10⁶/L	7	10	.037*	4	10	.017*	10	4	.0096*	10	5	.022*
%	3.01	3.15	.85	2.7	2.9	.83	3.2	2.4	.17	3.1	2.3	.28
BAFF, ng/mL	1.7	0.76	.0001*	2.3	1.1	.04*	1.78	1.9	.39	1.6	0.8	.18
IgG, mg/dL	1955	1124	.001*	1168	1113	.82	1396	1108	.65	1324	1106	.17
Ratio BAFF/immature B cells	0.09	0.05	.01*	0.12	0.07	.09	0.01	0.02	.9	0.12	0.06	.4
Ratio BAFF/memory B cells	0.17	0.04	.02*	0.24	0.12	.4	0.12	0.15	.86	0.18	0.04	.33
Ratio BAFF/CD19⁺ B cells	0.01	0.004	.08	0.01	0.0063	.03*	0.21	0.23	.4	0.01	0.002	.5

Parameter	Scleroderma			Bronchiolitis obliteraus			Mild/moderate vs severe			≤ 2 vs > 2 organs involved
Parameter	Yes	No	P	Yes	No	P	Mild/moderate	Severe	P	≤ 2	> 2	P
CD19⁺ B cells × 10⁶/L	302	453	.06	258	428	.041*	420	207	.07	405	227	.019*
Immature B cells absolute × 10⁶/L	26	28	.74	25	28	.57	26	26	.7	31	23	.8
%	14.1	7.7	.02*	16.1	8.04	.002*	9.2	14.5	.54	9.2	5.7	.07
Transitional B cells absolute × 10⁶/L	26	23	.78	11	23	.25	19	18	.6	22	15	.3
%	7.2	4.1	.18	4	6.2	.38	7.2	7	.48	6.1	3.6	.15
Naive B cells absolute × 10⁶/L	270	380	.2	200	360	.05	360	170	.07	340	170	.03*
%	84	84	.9	77	85	.0089*	86	79	.012*	85	83	.58
Class-switched memory B cells absolute × 10⁶/L	10	40	.005*	25	30	.6	26	11	.44	30	10	.038*
%	6.1	8	.28	9	7.6	.41	6.3	7.8	.03*	6.3	7.9	.55
Non–class-switched memory B cells absolute × 10⁶/L	7	10	.037*	4	10	.017*	10	4	.0096*	10	5	.022*
%	3.01	3.15	.85	2.7	2.9	.83	3.2	2.4	.17	3.1	2.3	.28
BAFF, ng/mL	1.7	0.76	.0001*	2.3	1.1	.04*	1.78	1.9	.39	1.6	0.8	.18
IgG, mg/dL	1955	1124	.001*	1168	1113	.82	1396	1108	.65	1324	1106	.17
Ratio BAFF/immature B cells	0.09	0.05	.01*	0.12	0.07	.09	0.01	0.02	.9	0.12	0.06	.4
Ratio BAFF/memory B cells	0.17	0.04	.02*	0.24	0.12	.4	0.12	0.15	.86	0.18	0.04	.33
Ratio BAFF/CD19⁺ B cells	0.01	0.004	.08	0.01	0.0063	.03*	0.21	0.23	.4	0.01	0.002	.5

Significant P value.