Optimal cut points of IHC markers used to predict OS*
| Marker* . | Optimal cut point selected† . | r-CHOP . | e-CHOP . | c-CHOP . | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI)‡ . | Log-rank P . | HR (95% CI)‡ . | Log-rank P . | HR (95% CI)‡ . | Log-rank P . | ||
| BCL2 | ≤ 75% vs > 75% | 1.4 (0.9, 2.2) | .09 | 1.7 (1.4, 2.1) | < .0001 | 1.6 (1.1, 2.3) | .02 |
| BCL6 | No staining vs staining | 1.1 (0.5, 2.7) | .76 | 1.7 (1.3, 2.3) | .0003 | 2.9 (1.7, 5.0) | < .0001 |
| CD5 | ≤ 75% vs > 75% | 2.4 (1.3, 4.3) | .003 | 1.6 (1.2, 2.2) | .004 | 1.0 (0.6, 1.9) | .9 |
| CD10 | Negative vs positive | 1.1 (0.8, 1.7) | .56 | 1.2 (0.9, 1.5) | .17 | 1.4 (1.0, 2.0) | .06 |
| HLA-DR | Negative vs positive | 1.3 (0.7, 2.4) | .36 | 1.6 (1.2, 2.1) | .001 | 1.3 (0.8, 1.9) | .33 |
| Ki67 | ≤ 75% vs > 75% | 1.8 (1.1, 2.9) | .02 | 0.8 (0.7, 1.0) | .11 | 1.0 (0.6, 1.5) | .86 |
| MUM1 | ≤ 75% vs > 75% | 1.4 (0.8, 2.3) | .22 | 1.3 (1.0, 1.7) | .03 | 1.5 (1.0, 2.4) | .06 |
| Marker* . | Optimal cut point selected† . | r-CHOP . | e-CHOP . | c-CHOP . | |||
|---|---|---|---|---|---|---|---|
| HR (95% CI)‡ . | Log-rank P . | HR (95% CI)‡ . | Log-rank P . | HR (95% CI)‡ . | Log-rank P . | ||
| BCL2 | ≤ 75% vs > 75% | 1.4 (0.9, 2.2) | .09 | 1.7 (1.4, 2.1) | < .0001 | 1.6 (1.1, 2.3) | .02 |
| BCL6 | No staining vs staining | 1.1 (0.5, 2.7) | .76 | 1.7 (1.3, 2.3) | .0003 | 2.9 (1.7, 5.0) | < .0001 |
| CD5 | ≤ 75% vs > 75% | 2.4 (1.3, 4.3) | .003 | 1.6 (1.2, 2.2) | .004 | 1.0 (0.6, 1.9) | .9 |
| CD10 | Negative vs positive | 1.1 (0.8, 1.7) | .56 | 1.2 (0.9, 1.5) | .17 | 1.4 (1.0, 2.0) | .06 |
| HLA-DR | Negative vs positive | 1.3 (0.7, 2.4) | .36 | 1.6 (1.2, 2.1) | .001 | 1.3 (0.8, 1.9) | .33 |
| Ki67 | ≤ 75% vs > 75% | 1.8 (1.1, 2.9) | .02 | 0.8 (0.7, 1.0) | .11 | 1.0 (0.6, 1.5) | .86 |
| MUM1 | ≤ 75% vs > 75% | 1.4 (0.8, 2.3) | .22 | 1.3 (1.0, 1.7) | .03 | 1.5 (1.0, 2.4) | .06 |
The number of the 1514 patients scored for BCL2, BCL6, CD5, CD10, HLA-dr, Ki67, MUM1, are 1306, 985, 1366, 1344, 1377, 1138, 1249, respectively
When optimal cut points were not determined using the r-CHOP series, the e-CHOP cut points are presented. Results obtained from applying the cut points to all cohorts are shown.
Reference groups: ≤ 75% staining for BCL2, CD5, MUM1, and Ki67; any staining for BCL6; positive for CD10 and HLA-DR.