Demographic and clinical characteristics of children with ALL with and without CRLF2 deregulation and stratified by DS status
| . | CRLF2 deregulation . | ||||||
|---|---|---|---|---|---|---|---|
| Total cohort . | Non-DS-ALL* . | DS-ALL* . | |||||
| Yes, n (%) . | No, n (%) . | P . | Yes, n (%) . | No, n (%) . | Yes, n (%) . | No, n (%) . | |
| Total | 52 (100) | 813 (100) | 38 (100) | 801 (100) | 14 (100) | 12 (100) | |
| Sex | .350 | ||||||
| Male | 25 (48) | 445 (55) | 15 (40) | 438 (55) | 10 (71) | 7 (58) | |
| Female | 27 (52) | 368 (45) | 23 (61) | 363 (45) | 4 (29) | 5 (42) | |
| Age, y | .100 | ||||||
| 1-4 | 27 (52) | 435 (54) | 19 (50) | 429 (54) | 8 (57) | 6 (50) | |
| 5-9 | 20 (39) | 222 (27) | 16 (42) | 217 (27) | 4 (29) | 5 (42) | |
| 10-18 | 5 (10) | 156 (19) | 3 (8) | 155 (19) | 2 (14) | 1 (8) | |
| NCI risk group | .507 | ||||||
| Standard | 35 (67) | 510 (63) | 25 (66) | 501 (63) | 10 (71) | 9 (75) | |
| High | 17 (33) | 303 (37) | 13 (34) | 300 (37) | 4 (29) | 3 (25) | |
| Ethnicity | .052 | ||||||
| White | 50 (96) | 694 (87) | 36 (95) | 685 (87) | 14 (100) | 9 (75) | |
| Nonwhite | 2 (4) | 104 (13) | 2 (5) | 101 (13) | 0 (0) | 3 (25) | |
| White cell count (× 109/L) | .776 | ||||||
| < 50 | 40 (77) | 639 (79) | 28 (74) | 629 (79) | 12 (86) | 10 (83) | |
| ≥ 50 | 12 (23) | 174 (21) | 10 (26) | 172 (22) | 2 (14) | 2 (17) | |
| CNS disease | > .999 | ||||||
| No | 52 (100) | 801 (99) | 38 (100) | 789 (99) | 12 (100) | 14 (100) | |
| Yes | 0 (0) | 12 (2) | 0 (0) | 12 (2) | 0 (0) | 0 (0) | |
| Marrow blasts | .016 | ||||||
| < 90% | 2 (4) | 158 (21) | 1 (3) | 155 (21) | 1 (8) | 3 (27) | |
| 90%-94% | 13 (27) | 141 (19) | 10 (27) | 139 (19) | 3 (25) | 2 (18) | |
| 95%-99% | 26 (53) | 373 (50) | 19 (51) | 367 (50) | 7 (58) | 6 (55) | |
| 100% | 8 (16) | 70 (9) | 7 (19) | 70 (10) | 1 (8) | 0 (0) | |
| Enlarged spleen | .003 | ||||||
| No | 29 (56) | 598 (75) | 21 (55) | 587 (74) | 8 (57) | 11 (92) | |
| Yes | 23 (44) | 204 (25) | 17 (45) | 203 (26) | 6 (43) | 1 (8) | |
| Enlarged liver | .001 | ||||||
| No | 29 (56) | 607 (76) | 21 (55) | 597 (76) | 8 (57) | 10 (83) | |
| Yes | 23 (44) | 194 (24) | 17 (45) | 192 (24) | 6 (43) | 2 (17) | |
| Enlarged liver and spleen | < .001 | ||||||
| No | 32 (62) | 654 (82) | 24 (63) | 643 (82) | 8 (57) | 11 (92) | |
| Yes | 20 (39) | 147 (18) | 14 (37) | 146 (19) | 6 (43) | 1 (8) | |
| AMM | .01 | ||||||
| No | 49 (94) | 786 (99) | 36 (95) | 774 (99) | 13 (93) | 12 (100) | |
| Yes | 3 (6) | 10 (1) | 2 (5) | 10 (1) | 1 (7) | 0 (0) | |
| . | CRLF2 deregulation . | ||||||
|---|---|---|---|---|---|---|---|
| Total cohort . | Non-DS-ALL* . | DS-ALL* . | |||||
| Yes, n (%) . | No, n (%) . | P . | Yes, n (%) . | No, n (%) . | Yes, n (%) . | No, n (%) . | |
| Total | 52 (100) | 813 (100) | 38 (100) | 801 (100) | 14 (100) | 12 (100) | |
| Sex | .350 | ||||||
| Male | 25 (48) | 445 (55) | 15 (40) | 438 (55) | 10 (71) | 7 (58) | |
| Female | 27 (52) | 368 (45) | 23 (61) | 363 (45) | 4 (29) | 5 (42) | |
| Age, y | .100 | ||||||
| 1-4 | 27 (52) | 435 (54) | 19 (50) | 429 (54) | 8 (57) | 6 (50) | |
| 5-9 | 20 (39) | 222 (27) | 16 (42) | 217 (27) | 4 (29) | 5 (42) | |
| 10-18 | 5 (10) | 156 (19) | 3 (8) | 155 (19) | 2 (14) | 1 (8) | |
| NCI risk group | .507 | ||||||
| Standard | 35 (67) | 510 (63) | 25 (66) | 501 (63) | 10 (71) | 9 (75) | |
| High | 17 (33) | 303 (37) | 13 (34) | 300 (37) | 4 (29) | 3 (25) | |
| Ethnicity | .052 | ||||||
| White | 50 (96) | 694 (87) | 36 (95) | 685 (87) | 14 (100) | 9 (75) | |
| Nonwhite | 2 (4) | 104 (13) | 2 (5) | 101 (13) | 0 (0) | 3 (25) | |
| White cell count (× 109/L) | .776 | ||||||
| < 50 | 40 (77) | 639 (79) | 28 (74) | 629 (79) | 12 (86) | 10 (83) | |
| ≥ 50 | 12 (23) | 174 (21) | 10 (26) | 172 (22) | 2 (14) | 2 (17) | |
| CNS disease | > .999 | ||||||
| No | 52 (100) | 801 (99) | 38 (100) | 789 (99) | 12 (100) | 14 (100) | |
| Yes | 0 (0) | 12 (2) | 0 (0) | 12 (2) | 0 (0) | 0 (0) | |
| Marrow blasts | .016 | ||||||
| < 90% | 2 (4) | 158 (21) | 1 (3) | 155 (21) | 1 (8) | 3 (27) | |
| 90%-94% | 13 (27) | 141 (19) | 10 (27) | 139 (19) | 3 (25) | 2 (18) | |
| 95%-99% | 26 (53) | 373 (50) | 19 (51) | 367 (50) | 7 (58) | 6 (55) | |
| 100% | 8 (16) | 70 (9) | 7 (19) | 70 (10) | 1 (8) | 0 (0) | |
| Enlarged spleen | .003 | ||||||
| No | 29 (56) | 598 (75) | 21 (55) | 587 (74) | 8 (57) | 11 (92) | |
| Yes | 23 (44) | 204 (25) | 17 (45) | 203 (26) | 6 (43) | 1 (8) | |
| Enlarged liver | .001 | ||||||
| No | 29 (56) | 607 (76) | 21 (55) | 597 (76) | 8 (57) | 10 (83) | |
| Yes | 23 (44) | 194 (24) | 17 (45) | 192 (24) | 6 (43) | 2 (17) | |
| Enlarged liver and spleen | < .001 | ||||||
| No | 32 (62) | 654 (82) | 24 (63) | 643 (82) | 8 (57) | 11 (92) | |
| Yes | 20 (39) | 147 (18) | 14 (37) | 146 (19) | 6 (43) | 1 (8) | |
| AMM | .01 | ||||||
| No | 49 (94) | 786 (99) | 36 (95) | 774 (99) | 13 (93) | 12 (100) | |
| Yes | 3 (6) | 10 (1) | 2 (5) | 10 (1) | 1 (7) | 0 (0) | |
ALL indicates acute lymphoblastic leukemia; AMM, anterior mediastinal mass; CNS, central nervous system; DS, Down syndrome; and NCI, National Cancer Institute.