Table 1 Characterization of T-ALL... | American Society of Hematology

Table 1

Characterization of T-ALL individuals with PTPN2 inactivation

Individual	Sex	Age, y	PTPN2 deletion*	PTPN2 mutation	Deregulated transcription factor†	NUP214-ABL1‡	JAK1 status
1§	F	30	PTPN2^−/−	NA	TLX1	−	wt
2§	M	24	PTPN2^−/−	NA	TLX1	+	wt
3§	F	27	PTPN2^−/−	NA	TLX1	−	wt
4§	M	21	PTPN2^−/−	NA	TLX1	−	wt
5§	M	45	PTPN2^−/−	NA	TLX1	+	wt
6§	M	8	PTPN2^−/−	NA	TLX3	−	c.1944A > C p.K648N
7§	M	43	PTPN2^−/−	NA	TLX1	−	wt
8§	M	20	PTPN2^−/−	NA	TLX1	−	wt
9§	F	4	PTPN2^+/−	wt	TLX1	+	wt
10§	M	11	PTPN2^+/−	wt	TLX1	−	wt
11§	F	35	PTPN2^+/−	wt	TLX1	−	wt
12§	F	9	PTPN2^+/−	wt	TLX1	+	wt
13§	F	49	PTPN2^+/−	c.862C > T, p.R288Stop	TLX1	−	c.1953T > C p.Y652H
14	M	34	PTPN2^−/−	NA	TLX1	−	wt
15	F	42	PTPN2^+/−	wt	TLX1	−	wt
16	F	38	PTPN2^+/−	wt	TLX1	+	wt
17	M	53	PTPN2^−/−	NA	TLX1	−	wt
18	M	28	PTPN2^−/−	NA	TLX1	+	wt

Individual	Sex	Age, y	PTPN2 deletion*	PTPN2 mutation	Deregulated transcription factor†	NUP214-ABL1‡	JAK1 status
1§	F	30	PTPN2^−/−	NA	TLX1	−	wt
2§	M	24	PTPN2^−/−	NA	TLX1	+	wt
3§	F	27	PTPN2^−/−	NA	TLX1	−	wt
4§	M	21	PTPN2^−/−	NA	TLX1	−	wt
5§	M	45	PTPN2^−/−	NA	TLX1	+	wt
6§	M	8	PTPN2^−/−	NA	TLX3	−	c.1944A > C p.K648N
7§	M	43	PTPN2^−/−	NA	TLX1	−	wt
8§	M	20	PTPN2^−/−	NA	TLX1	−	wt
9§	F	4	PTPN2^+/−	wt	TLX1	+	wt
10§	M	11	PTPN2^+/−	wt	TLX1	−	wt
11§	F	35	PTPN2^+/−	wt	TLX1	−	wt
12§	F	9	PTPN2^+/−	wt	TLX1	+	wt
13§	F	49	PTPN2^+/−	c.862C > T, p.R288Stop	TLX1	−	c.1953T > C p.Y652H
14	M	34	PTPN2^−/−	NA	TLX1	−	wt
15	F	42	PTPN2^+/−	wt	TLX1	−	wt
16	F	38	PTPN2^+/−	wt	TLX1	+	wt
17	M	53	PTPN2^−/−	NA	TLX1	−	wt
18	M	28	PTPN2^−/−	NA	TLX1	+	wt

Determined by FISH, quantitative PCR, or aCGH; ^−/− indicates a biallelic deletion; and ^+/−, a monoallelic deletion.

Positivity for TLX1 or TLX3 expression.

Positivity for NUP214-ABL1 expression or rearrangement; + indicates positive for NUP214-ABL1; and −, negative for NUP214-ABL1.

Patient results have been published previously and are consecutively numbered.¹⁵

NA indicates not applicable; and wt, wild-type.