Clinical improvement and the change of EBV-DNA copies in the patients
| Case . | Clinical outcomes . | Plasma EBV-DNA copies/mL in patients' before infusion . | EBV-DNA copies in patients' 15-30 d after the first infusion . |
|---|---|---|---|
| 1 | Lymph nodes in his neck became smaller after 3-5 days. Skin rashes decreased, and the temperature was back to normal. Two months after the first infusion, the fever and lymphadenopathy recurred; he then received another 3 infusions from his mother. Lymph nodes became smaller within a week after each infusion, but intermittent fever and lymphadenopathy happened 1-2 months after each infusion. He only got a partial remission and did not continue the therapy. | − | − |
| 2 | His rashes and lymphadenopathy improved in a week after the first infusion. Low-grade intermittent fever lasted for 2 months. He received another 3 infusions from his mother, the fever stopped, rashes disappeared, and no lymphadenopathy occurred. After 17 months, he has achieved complete remission | 6.0 | − |
| 3 | Abnormal liver function disappeared. Spleen became unpalpable. Ultrasonography showed reduction of liver and spleen sizes. Low-grade intermittent fever lasted for 3 months. Thirteen months later, he remained afebrile. He had a complete remission. | 8.0 | − |
| 4 | Parotid gland became smaller a week after the infusion; intermittent fever lasted for ∼ 1-2 months. Ten months after the infusion, he remained afebrile with good health and impalpable parotid gland. | 2.0 | No data |
| 5 | The temperature returned to normal 3 days after the infusion, and the ultrasonography showed reduction of liver and spleen sizes within 2 weeks. Two months later, the fever and hepatosplenomegaly recurred. He then prepared for HSCT. | 6.7 | − |
| Case . | Clinical outcomes . | Plasma EBV-DNA copies/mL in patients' before infusion . | EBV-DNA copies in patients' 15-30 d after the first infusion . |
|---|---|---|---|
| 1 | Lymph nodes in his neck became smaller after 3-5 days. Skin rashes decreased, and the temperature was back to normal. Two months after the first infusion, the fever and lymphadenopathy recurred; he then received another 3 infusions from his mother. Lymph nodes became smaller within a week after each infusion, but intermittent fever and lymphadenopathy happened 1-2 months after each infusion. He only got a partial remission and did not continue the therapy. | − | − |
| 2 | His rashes and lymphadenopathy improved in a week after the first infusion. Low-grade intermittent fever lasted for 2 months. He received another 3 infusions from his mother, the fever stopped, rashes disappeared, and no lymphadenopathy occurred. After 17 months, he has achieved complete remission | 6.0 | − |
| 3 | Abnormal liver function disappeared. Spleen became unpalpable. Ultrasonography showed reduction of liver and spleen sizes. Low-grade intermittent fever lasted for 3 months. Thirteen months later, he remained afebrile. He had a complete remission. | 8.0 | − |
| 4 | Parotid gland became smaller a week after the infusion; intermittent fever lasted for ∼ 1-2 months. Ten months after the infusion, he remained afebrile with good health and impalpable parotid gland. | 2.0 | No data |
| 5 | The temperature returned to normal 3 days after the infusion, and the ultrasonography showed reduction of liver and spleen sizes within 2 weeks. Two months later, the fever and hepatosplenomegaly recurred. He then prepared for HSCT. | 6.7 | − |
– indicates EBV-DNA was undetectable; and no data, no test had been performed.