Fever and infection during neutropenia
| . | Granulocyte colony-stimulating factor responsiveness . | P . | ||
|---|---|---|---|---|
| Low, n = 43 . | Medium, n = 42 . | High, = 83 . | ||
| Fever and neutropenia, % | ||||
| Fever > 38°C | 84 | 62 | 51 | .0004 |
| Febrile neutropenia | 77 | 60 | 48 | .0037 |
| Documented infections, % | ||||
| Bacteremia | 12 | 17 | 11 | |
| Pneumonia | 7 | 12 | 1 | |
| Enterocolitis | 7 | 7 | 1 | |
| Fungal infection | 2 | – | – | |
| Viral infection | 5 | 5 | 1 | |
| Urinary tract infection | 2 | – | 2 | |
| Stomatitis | 2 | 2 | 1 | |
| Catheter infection | – | 2 | 1 | |
| Others | 5 | 5 | 6 | |
| Categories of infection, % | ||||
| Microbially defined (type A) | 16 | 29 | 16 | .73 |
| Clinically defined (type B) | 23 | 21 | 8 | .01 |
| Fever of unknown origin (type C) | 65 | 38 | 33 | .0013 |
| Primary composite end points, % | ||||
| Initial (type A + B) | 30 | 43 | 24 | .32 |
| Amended (type A + B + C) | 91 | 67 | 54 | < .0001 |
| . | Granulocyte colony-stimulating factor responsiveness . | P . | ||
|---|---|---|---|---|
| Low, n = 43 . | Medium, n = 42 . | High, = 83 . | ||
| Fever and neutropenia, % | ||||
| Fever > 38°C | 84 | 62 | 51 | .0004 |
| Febrile neutropenia | 77 | 60 | 48 | .0037 |
| Documented infections, % | ||||
| Bacteremia | 12 | 17 | 11 | |
| Pneumonia | 7 | 12 | 1 | |
| Enterocolitis | 7 | 7 | 1 | |
| Fungal infection | 2 | – | – | |
| Viral infection | 5 | 5 | 1 | |
| Urinary tract infection | 2 | – | 2 | |
| Stomatitis | 2 | 2 | 1 | |
| Catheter infection | – | 2 | 1 | |
| Others | 5 | 5 | 6 | |
| Categories of infection, % | ||||
| Microbially defined (type A) | 16 | 29 | 16 | .73 |
| Clinically defined (type B) | 23 | 21 | 8 | .01 |
| Fever of unknown origin (type C) | 65 | 38 | 33 | .0013 |
| Primary composite end points, % | ||||
| Initial (type A + B) | 30 | 43 | 24 | .32 |
| Amended (type A + B + C) | 91 | 67 | 54 | < .0001 |