Characteristics of patients with or without WT1 mutations
| . | WT1 mutant . | WT1 wild-type . | P . |
|---|---|---|---|
| Study | |||
| CCG-2941 | 1 (1.4) | 38 (4.9) | .243 |
| CCG-2961 | 46 (65.7) | 495 (64.1) | .891 |
| AAML03P1 | 23 (32.9) | 239 (31.0) | .846 |
| Sex | |||
| Male | 37 (52.9) | 411 (53.2) | .949 |
| Female | 33 (47.1) | 361 (46.8) | |
| Age, y | |||
| Median (range) | 11.5 (0.85-18.3) | 10.1 (0.01-21.63) | .031* |
| 0-2 | 5 (7.1) | 193 (25.0) | .001* |
| 3-10 | 25 (35.7) | 225 (29.1) | .310 |
| 11-21 | 40 (57.1) | 354 (5.9) | .092 |
| Race | |||
| White | 47 (67.1) | 492 (65.1) | .829 |
| Black | 12 (17.1) | 85 (11.2) | .203 |
| Hispanic | 8 (1.4) | 125 (16.5) | .346 |
| Asian | 2 (2.9) | 26 (3.4) | .999 |
| Other | 1 (1.4) | 28 (3.7) | .503 |
| Unknown | 0 | 16 | |
| WBC count, × 103/μL, median (range) | 35 (1.2-3260) | 20.5 (0.3-860) | .145 |
| BM blasts, % | 75.5 (5-100) | 70 (0-100) | .122 |
| Platelet count, ×103/μL, median (range) | 54 (4-800) | 47.5 (2-46 000) | .252 |
| Hemoglobin level, g/dL, median (range) | 8.2 (3.1-13.7) | 8.3 (0.4-38.6) | .935 |
| FAB classification | |||
| M0 | 3 (4.5) | 32 (4.4) | .999 |
| M1 | 11 (16.4) | 119 (16.3) | .875 |
| M2 | 22 (32.8) | 202 (27.7) | .457 |
| M4 | 23 (34.3) | 191 (26.2) | .199 |
| M5 | 4 (6.0) | 136 (18.7) | .014* |
| M6 | 2 (3.0) | 15 (2.1) | .648 |
| M7 | 2 (3.0) | 33 (4.5) | .760 |
| Other/no data, n | 3 | 44 | |
| Cytogenetics | |||
| Normal | 18 (35.3) | 108 (20.0) | .017* |
| t(8;21) | 5 (9.8) | 87 (16.1) | .327 |
| inv(16) | 9 (17.6) | 62 (11.5) | .283 |
| Abnormal 11 | 4 (7.8) | 125 (23.1) | .019* |
| t(6;9)(p23;q34) | 3 (5.9) | 9 (1.7) | .076 |
| −7/7q− | 2 (3.9) | 18 (3.3) | .687 |
| −5/5q− | 0 (0.0) | 7 (1.3) | .999 |
| +8 | 3 (5.9) | 41 (7.6) | .999 |
| +21 | 0 (0.0) | 4 (0.7) | .999 |
| Pseudodiploid | 4 (7.8) | 31 (5.7) | .531 |
| Hyperdiploid | 2 (3.9) | 8 (1.5) | .210 |
| Hypodiploid | 0 (0.0) | 5 (0.9) | .999 |
| Other | 1 (2.0) | 36 (6.7) | .356 |
| Unknown, n | 19 | 231 | |
| FLT3/ITD status | |||
| ITD+ | 25 (35.7) | 76 (9.8) | < .001* |
| ITD− | 45 (64.3) | 696 (90.2) | |
| Missing, n | 0 | 0 | |
| FLT3 PM status | |||
| FLT3 PM+ | 5 (7.1) | 47 (6.1) | .611 |
| FLT3 PM− | 65 (92.9) | 725 (93.9) | |
| Missing, n | 0 | 0 | |
| CEBPA status | |||
| CEBPA mutant | 3 (4.5) | 28 (3.9) | .743 |
| CEBPA WT | 64 (95.5) | 688 (96.1) | |
| Missing, n | 3 | 56 | |
| NPM status | |||
| NPM mutant | 3 (4.3) | 43 (6.4) | .792 |
| NPM WT | 67 (95.7) | 632 (93.6) | |
| Missing, n | 0 | 97 | |
| Course 1 response | |||
| CR | 49 (72.1) | 603 (80.6) | .127 |
| Not in CR | 19 (27.9) | 145 (19.4) | |
| Unevaluable, n | 27 | 24 | |
| Course 2 response | |||
| CR | 44 (69.8) | 547 (77.6) | .355 |
| Not in CR | 19 (30.2) | 158 (22.4) | |
| Unevaluable, n | 7 | 67 |
| . | WT1 mutant . | WT1 wild-type . | P . |
|---|---|---|---|
| Study | |||
| CCG-2941 | 1 (1.4) | 38 (4.9) | .243 |
| CCG-2961 | 46 (65.7) | 495 (64.1) | .891 |
| AAML03P1 | 23 (32.9) | 239 (31.0) | .846 |
| Sex | |||
| Male | 37 (52.9) | 411 (53.2) | .949 |
| Female | 33 (47.1) | 361 (46.8) | |
| Age, y | |||
| Median (range) | 11.5 (0.85-18.3) | 10.1 (0.01-21.63) | .031* |
| 0-2 | 5 (7.1) | 193 (25.0) | .001* |
| 3-10 | 25 (35.7) | 225 (29.1) | .310 |
| 11-21 | 40 (57.1) | 354 (5.9) | .092 |
| Race | |||
| White | 47 (67.1) | 492 (65.1) | .829 |
| Black | 12 (17.1) | 85 (11.2) | .203 |
| Hispanic | 8 (1.4) | 125 (16.5) | .346 |
| Asian | 2 (2.9) | 26 (3.4) | .999 |
| Other | 1 (1.4) | 28 (3.7) | .503 |
| Unknown | 0 | 16 | |
| WBC count, × 103/μL, median (range) | 35 (1.2-3260) | 20.5 (0.3-860) | .145 |
| BM blasts, % | 75.5 (5-100) | 70 (0-100) | .122 |
| Platelet count, ×103/μL, median (range) | 54 (4-800) | 47.5 (2-46 000) | .252 |
| Hemoglobin level, g/dL, median (range) | 8.2 (3.1-13.7) | 8.3 (0.4-38.6) | .935 |
| FAB classification | |||
| M0 | 3 (4.5) | 32 (4.4) | .999 |
| M1 | 11 (16.4) | 119 (16.3) | .875 |
| M2 | 22 (32.8) | 202 (27.7) | .457 |
| M4 | 23 (34.3) | 191 (26.2) | .199 |
| M5 | 4 (6.0) | 136 (18.7) | .014* |
| M6 | 2 (3.0) | 15 (2.1) | .648 |
| M7 | 2 (3.0) | 33 (4.5) | .760 |
| Other/no data, n | 3 | 44 | |
| Cytogenetics | |||
| Normal | 18 (35.3) | 108 (20.0) | .017* |
| t(8;21) | 5 (9.8) | 87 (16.1) | .327 |
| inv(16) | 9 (17.6) | 62 (11.5) | .283 |
| Abnormal 11 | 4 (7.8) | 125 (23.1) | .019* |
| t(6;9)(p23;q34) | 3 (5.9) | 9 (1.7) | .076 |
| −7/7q− | 2 (3.9) | 18 (3.3) | .687 |
| −5/5q− | 0 (0.0) | 7 (1.3) | .999 |
| +8 | 3 (5.9) | 41 (7.6) | .999 |
| +21 | 0 (0.0) | 4 (0.7) | .999 |
| Pseudodiploid | 4 (7.8) | 31 (5.7) | .531 |
| Hyperdiploid | 2 (3.9) | 8 (1.5) | .210 |
| Hypodiploid | 0 (0.0) | 5 (0.9) | .999 |
| Other | 1 (2.0) | 36 (6.7) | .356 |
| Unknown, n | 19 | 231 | |
| FLT3/ITD status | |||
| ITD+ | 25 (35.7) | 76 (9.8) | < .001* |
| ITD− | 45 (64.3) | 696 (90.2) | |
| Missing, n | 0 | 0 | |
| FLT3 PM status | |||
| FLT3 PM+ | 5 (7.1) | 47 (6.1) | .611 |
| FLT3 PM− | 65 (92.9) | 725 (93.9) | |
| Missing, n | 0 | 0 | |
| CEBPA status | |||
| CEBPA mutant | 3 (4.5) | 28 (3.9) | .743 |
| CEBPA WT | 64 (95.5) | 688 (96.1) | |
| Missing, n | 3 | 56 | |
| NPM status | |||
| NPM mutant | 3 (4.3) | 43 (6.4) | .792 |
| NPM WT | 67 (95.7) | 632 (93.6) | |
| Missing, n | 0 | 97 | |
| Course 1 response | |||
| CR | 49 (72.1) | 603 (80.6) | .127 |
| Not in CR | 19 (27.9) | 145 (19.4) | |
| Unevaluable, n | 27 | 24 | |
| Course 2 response | |||
| CR | 44 (69.8) | 547 (77.6) | .355 |
| Not in CR | 19 (30.2) | 158 (22.4) | |
| Unevaluable, n | 7 | 67 |
Data are reported as n (%) except where otherwise noted. BM indicates bone marrow; FAB, French-American-British; PM, point mutation; and WT, wild-type.
Statistically significant (P = .05).