Pimozide does not directly inhibit tyrosine kinase activity
| Kinase . | % inhibition of kinase activity . | |
|---|---|---|
| Pimozide . | Imatinib . | |
| ABL1 | < 5 | 40 |
| ABL1 T315I | < 5 | < 5 |
| HCK | < 5 | ND |
| LYN A | < 5 | ND |
| LYN B | < 5 | ND |
| SRC | 7 | ND |
| Kinase . | % inhibition of kinase activity . | |
|---|---|---|
| Pimozide . | Imatinib . | |
| ABL1 | < 5 | 40 |
| ABL1 T315I | < 5 | < 5 |
| HCK | < 5 | ND |
| LYN A | < 5 | ND |
| LYN B | < 5 | ND |
| SRC | 7 | ND |
The effect of pimozide on the activity of selected tyrosine kinases was analyzed using the SelectScreen Kinase Profiling service (Invitrogen).
ND indicates not determined.