Serial detection of both CB units according to unit-unit HLA match
Time post-CBT . | No. of patients with both units detected in blood or bone marrow (%) . | |||||
---|---|---|---|---|---|---|
Unit-unit match at HLA-A, HLA-B antigen, and HLA-DRB1 allele level . | Unit-unit HLA match at 10 allele level . | |||||
1/6-4/6 . | 5/6-6/6 . | P . | 1/10-6/10 . | 7/10-10/10 . | P . | |
Day 21, (n = 83) | 3/56 (5) | 13/27 (48) | < .0001 | 2/56 (4) | 14/27 (52) | < .0001 |
Day 28, (n = 79) | 2/54 (4) | 12/25 (48) | < .0001 | 0/54 (0) | 14/25 (56) | < .0001 |
Day 60, (n = 72) | 2/47 (4) | 6/25 (24) | .02 | 0/47 (0) | 8/25 (32) | < .0001 |
Day 100, (n = 68) | 0/46 (0) | 3/22 (14) | .03 | 0/45 (0) | 3/23 (13) | .04 |
Day 180, (n = 56) | 0/40 (0) | 2/16 (12) | .08 | 0/38 (0) | 2/18 (11) | .10 |
Day 365, (n = 43) | 0/30 (0) | 1/13 (8) | .30 | 0/30 (0) | 1/13 (8) | .30 |
Time post-CBT . | No. of patients with both units detected in blood or bone marrow (%) . | |||||
---|---|---|---|---|---|---|
Unit-unit match at HLA-A, HLA-B antigen, and HLA-DRB1 allele level . | Unit-unit HLA match at 10 allele level . | |||||
1/6-4/6 . | 5/6-6/6 . | P . | 1/10-6/10 . | 7/10-10/10 . | P . | |
Day 21, (n = 83) | 3/56 (5) | 13/27 (48) | < .0001 | 2/56 (4) | 14/27 (52) | < .0001 |
Day 28, (n = 79) | 2/54 (4) | 12/25 (48) | < .0001 | 0/54 (0) | 14/25 (56) | < .0001 |
Day 60, (n = 72) | 2/47 (4) | 6/25 (24) | .02 | 0/47 (0) | 8/25 (32) | < .0001 |
Day 100, (n = 68) | 0/46 (0) | 3/22 (14) | .03 | 0/45 (0) | 3/23 (13) | .04 |
Day 180, (n = 56) | 0/40 (0) | 2/16 (12) | .08 | 0/38 (0) | 2/18 (11) | .10 |
Day 365, (n = 43) | 0/30 (0) | 1/13 (8) | .30 | 0/30 (0) | 1/13 (8) | .30 |
A higher level of HLA match between the units was associated with engraftment of both units, and this finding was detected at both levels of resolution of HLA match. Incomplete data are a result of time point not reached, lack of assessment during critical illness, or patient death.