Association between viability of CD34+ cells in the dominant unit and the risk of graft failure
| CD34+ cell viability of dominant unit . | Patients with sustained donor engraftment, n = 79 (%) . | Patients with graft failure, n = 5 (%)* . | P . |
|---|---|---|---|
| ≥ 75% | 76 (96) | 3 (60) | .03 |
| < 75% | 3 (4) | 2 (40) |
| CD34+ cell viability of dominant unit . | Patients with sustained donor engraftment, n = 79 (%) . | Patients with graft failure, n = 5 (%)* . | P . |
|---|---|---|---|
| ≥ 75% | 76 (96) | 3 (60) | .03 |
| < 75% | 3 (4) | 2 (40) |
Engrafting patients were more likely to have dominant units with a high CD34+ cell viability (≥ 75% after thaw).
Patients with clinical graft failure had a dominant unit detected by chimerism studies, but the donor hematopoiesis did not result in sustained count recovery.