Table 2 Fitted regression equations for... | American Society of Hematology

Table 2

Fitted regression equations for modeling daily dose requirements based on age and VKORC1 and CYP2C9 genotypes

	Regression equation	P	R² model, %
Model variable
Age	√D = 0.46 − 0.011(age)	< .001	28.3
VKORC1	√D = 0.3 − 0.05(VKORC1[AA]) − 0.003 VKORC1[GA])	.28	3.7
CYP2C9	√D = 0.29 − 0.01(CYP2C9)	.61	0.4
Full model
Age, VKORC1, CYP2C9	√D = 0.49 − 0.013(age) − 0.08(VKORC1AA]) + 0.01(VKORC1[GA]) − 0.02(Cyp2C9)	< .001	38.2

	Regression equation	P	R² model, %
Model variable
Age	√D = 0.46 − 0.011(age)	< .001	28.3
VKORC1	√D = 0.3 − 0.05(VKORC1[AA]) − 0.003 VKORC1[GA])	.28	3.7
CYP2C9	√D = 0.29 − 0.01(CYP2C9)	.61	0.4
Full model
Age, VKORC1, CYP2C9	√D = 0.49 − 0.013(age) − 0.08(VKORC1AA]) + 0.01(VKORC1[GA]) − 0.02(Cyp2C9)	< .001	38.2