Demographics and baseline characteristics of subjects
| Characteristic . | Experiment 1, warfarin only (n = 11) . | Experiment 2 . | |||||
|---|---|---|---|---|---|---|---|
| Warfarin and placebo (n = 24) . | Warfarin and rFVIIa . | ||||||
| 5 μg/kg (n = 6) . | 10 μg/kg (n = 6) . | 20 μg/kg (n = 13) . | 40 μg/kg (n = 12) . | 80 μg/kg (n = 24) . | |||
| Mean age, y, ± SD | 26.5 ± 8.7 | 27.2 ± 7.3 | 26.4 ± 5.2 | 30.0 ± 10.2 | 25.3 ± 6.9 | 28.4 ± 7.5 | 25.3 ± 7.0 |
| Mean BMI, kg/m2, ± SD | 25.3 ± 3.2 | 25.7 ± 5.0 | 25.1 ± 4.9 | 24.2 ± 5.0 | 25.9 ± 4.9 | 26.7 ± 4.2 | 26.5 ± 3.5 |
| Ethnicity, n (%) | |||||||
| White | 10 (90.9) | 20 (83.3) | 6 (100.0) | 6 (100.0) | 12 (92.3) | 12 (100.0) | 24 (100.0) |
| Hispanic | 1 (9.1) | 1 (4.2) | 0 | 0 | 0 | 0 | 0 |
| Other | 0 | 3 (12.5) | 0 | 0 | 1 (7.7) | 0 | 0 |
| Characteristic . | Experiment 1, warfarin only (n = 11) . | Experiment 2 . | |||||
|---|---|---|---|---|---|---|---|
| Warfarin and placebo (n = 24) . | Warfarin and rFVIIa . | ||||||
| 5 μg/kg (n = 6) . | 10 μg/kg (n = 6) . | 20 μg/kg (n = 13) . | 40 μg/kg (n = 12) . | 80 μg/kg (n = 24) . | |||
| Mean age, y, ± SD | 26.5 ± 8.7 | 27.2 ± 7.3 | 26.4 ± 5.2 | 30.0 ± 10.2 | 25.3 ± 6.9 | 28.4 ± 7.5 | 25.3 ± 7.0 |
| Mean BMI, kg/m2, ± SD | 25.3 ± 3.2 | 25.7 ± 5.0 | 25.1 ± 4.9 | 24.2 ± 5.0 | 25.9 ± 4.9 | 26.7 ± 4.2 | 26.5 ± 3.5 |
| Ethnicity, n (%) | |||||||
| White | 10 (90.9) | 20 (83.3) | 6 (100.0) | 6 (100.0) | 12 (92.3) | 12 (100.0) | 24 (100.0) |
| Hispanic | 1 (9.1) | 1 (4.2) | 0 | 0 | 0 | 0 | 0 |
| Other | 0 | 3 (12.5) | 0 | 0 | 1 (7.7) | 0 | 0 |