Cumulative incidence of molecular response, by genotype
| Allelic variant . | No. (%) . | Major molecular response (MMR) . | Complete molecular response (CMR) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| At 1 y, % (SE) . | Univariate . | Multivariate† . | At 1 y, % (SE) . | Univariate . | Multivariate† . | ||||||
| HR (95% CI) . | P* . | HR (95% CI) . | P* . | HR (95% CI) . | P* . | HR (95% CI) . | P* . | ||||
| All patients | 46 | 59 (7) | 22 (6) | ||||||||
| C1236T, n = 43 | |||||||||||
| CC | 12 (28) | 92 (8) | 1 | .02 | 1 | .03 | 42 (14) | 1 | .06 | 1 | .01 |
| CT | 23 (53) | 52 (10) | .32 (.14-.71) | .31 (.13-.71) | 13 (7) | .36 (.16-.82) | .25 (.10-.63) | ||||
| TT | 8 (19) | 50 (18) | .33 (.12-.89) | .40 (.14-1.15) | 25 (15) | .48 (.17-1.39) | .27 (.08-.97) | ||||
| G2677T, n = 41 | |||||||||||
| GG | 10 (24) | 90 (9) | 1 | .11 | 1 | .21 | 40 (15) | 1 | .13 | 1 | .05 |
| GT | 23 (56) | 61 (10) | .45 (.20-1.05) | .49 (.20-1.16) | 22 (9) | .46 (.20-1.08) | .33 (.13-.85) | ||||
| TT | 8 (20) | 38 (17) | .36 (.13-.99) | .42 (.15-1.21) | 13 (12) | .35 (.11-1.13) | .23 (.06-.88) | ||||
| C3435T, n = 44 | |||||||||||
| CC | 10 (23) | 90 (9) | 1 | .04 | 1 | .06 | 50 (16) | 1 | .10 | 1 | .04 |
| CT | 24 (55) | 58 (10) | .37 (.16-.83) | .35 (.15-.82) | 17 (8) | .39 (.17-.92) | .33 (.13-.81) | ||||
| TT | 10 (23) | 40 (15) | .31 (.12-.83) | .35 (.12-.98) | 10 (9) | .39 (.13-1.17) | .24 (.07-.83) | ||||
| Allelic variant . | No. (%) . | Major molecular response (MMR) . | Complete molecular response (CMR) . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| At 1 y, % (SE) . | Univariate . | Multivariate† . | At 1 y, % (SE) . | Univariate . | Multivariate† . | ||||||
| HR (95% CI) . | P* . | HR (95% CI) . | P* . | HR (95% CI) . | P* . | HR (95% CI) . | P* . | ||||
| All patients | 46 | 59 (7) | 22 (6) | ||||||||
| C1236T, n = 43 | |||||||||||
| CC | 12 (28) | 92 (8) | 1 | .02 | 1 | .03 | 42 (14) | 1 | .06 | 1 | .01 |
| CT | 23 (53) | 52 (10) | .32 (.14-.71) | .31 (.13-.71) | 13 (7) | .36 (.16-.82) | .25 (.10-.63) | ||||
| TT | 8 (19) | 50 (18) | .33 (.12-.89) | .40 (.14-1.15) | 25 (15) | .48 (.17-1.39) | .27 (.08-.97) | ||||
| G2677T, n = 41 | |||||||||||
| GG | 10 (24) | 90 (9) | 1 | .11 | 1 | .21 | 40 (15) | 1 | .13 | 1 | .05 |
| GT | 23 (56) | 61 (10) | .45 (.20-1.05) | .49 (.20-1.16) | 22 (9) | .46 (.20-1.08) | .33 (.13-.85) | ||||
| TT | 8 (20) | 38 (17) | .36 (.13-.99) | .42 (.15-1.21) | 13 (12) | .35 (.11-1.13) | .23 (.06-.88) | ||||
| C3435T, n = 44 | |||||||||||
| CC | 10 (23) | 90 (9) | 1 | .04 | 1 | .06 | 50 (16) | 1 | .10 | 1 | .04 |
| CT | 24 (55) | 58 (10) | .37 (.16-.83) | .35 (.15-.82) | 17 (8) | .39 (.17-.92) | .33 (.13-.81) | ||||
| TT | 10 (23) | 40 (15) | .31 (.12-.83) | .35 (.12-.98) | 10 (9) | .39 (.13-1.17) | .24 (.07-.83) | ||||