Table 1 Mouse model targeting strategy... | American Society of Hematology

Table 1

Mouse model targeting strategy and observed phenotype

First author	Construct	JAK2-V617F	loxP	Hb, g/L	WBC, ×10⁹/L	Plt, ×10⁹/L	Myelofibrosis
Li¹	Knock-in	Human cDNA	Yes	150-170*	10-12	1500-1800	No†
Akada¹⁰	Knock-in	Mouse gene	Yes	200-230	20-35	1300-2000	Yes
Marty¹¹	Knock-in	Mouse gene	No	na	50-70	3500-4500	Yes
Tiedt⁷	JAK2-BAC	Human gene	Yes (MxCre)	180-220	10-40	3000-6000	Yes
Tiedt⁷	JAK2-BAC	Human gene	Yes (VavCre)	140-170	15-25	6000-14 000	Yes
Shide⁸	H2K prom.	Mouse cDNA	No	na	10-50	1000-5000	Yes
Xing⁹	Vav prom.	Mouse cDNA	No	180 ± 14	11 ± 3	2700 ± 700	Yes

First author	Construct	JAK2-V617F	loxP	Hb, g/L	WBC, ×10⁹/L	Plt, ×10⁹/L	Myelofibrosis
Li¹	Knock-in	Human cDNA	Yes	150-170*	10-12	1500-1800	No†
Akada¹⁰	Knock-in	Mouse gene	Yes	200-230	20-35	1300-2000	Yes
Marty¹¹	Knock-in	Mouse gene	No	na	50-70	3500-4500	Yes
Tiedt⁷	JAK2-BAC	Human gene	Yes (MxCre)	180-220	10-40	3000-6000	Yes
Tiedt⁷	JAK2-BAC	Human gene	Yes (VavCre)	140-170	15-25	6000-14 000	Yes
Shide⁸	H2K prom.	Mouse cDNA	No	na	10-50	1000-5000	Yes
Xing⁹	Vav prom.	Mouse cDNA	No	180 ± 14	11 ± 3	2700 ± 700	Yes

Hb indicates hemoglobin; WBC, white blood count; Plt, platelet count; BAC, bacterial artificial chromosome; and na, not available.

Approximately 10% of mice developed higher hemoglobin values at 26 weeks.

Except in 1 mouse.