Trabecular bone microarchitecture in distal femoral metaphysis and third lumbar vertebral body from 4-week-old WT and Krox20+/− mice
| . | Distal femur . | L3 vertebral body . | ||||
|---|---|---|---|---|---|---|
| Krox20+/+ (n = 5) . | Krox20+/− (n = 5) . | P . | Krox20+/+ (n = 7) . | Krox20+/− (n = 5) . | P . | |
| BV/TV (%) | 6.9 ± 0.8 | 4.7 ± 0.5 | .034 | 13.6 ± 1.0 | 10.6 ± 0.9 | .028 |
| Tb.N (mm−1) | 1.8 ± 0.1 | 1.3 ± 0.1 | .017 | 3.8 ± 0.2 | 3.2 ± 0.2 | .024 |
| Tb.Th (μm) | 38 ± 0.2 | 36 ± 0.1 | .225 | 35 ± 0.1 | 32 ± 0.1 | .077 |
| Conn.D (mm−3) | 29.5 ± 5.8 | 16.5 ± 2.8 | .046 | 109.7 ± 10.8 | 71.1 ± 10.6 | .015 |
| . | Distal femur . | L3 vertebral body . | ||||
|---|---|---|---|---|---|---|
| Krox20+/+ (n = 5) . | Krox20+/− (n = 5) . | P . | Krox20+/+ (n = 7) . | Krox20+/− (n = 5) . | P . | |
| BV/TV (%) | 6.9 ± 0.8 | 4.7 ± 0.5 | .034 | 13.6 ± 1.0 | 10.6 ± 0.9 | .028 |
| Tb.N (mm−1) | 1.8 ± 0.1 | 1.3 ± 0.1 | .017 | 3.8 ± 0.2 | 3.2 ± 0.2 | .024 |
| Tb.Th (μm) | 38 ± 0.2 | 36 ± 0.1 | .225 | 35 ± 0.1 | 32 ± 0.1 | .077 |
| Conn.D (mm−3) | 29.5 ± 5.8 | 16.5 ± 2.8 | .046 | 109.7 ± 10.8 | 71.1 ± 10.6 | .015 |
Data are mean ± SEM.
BV/TV indicates trabecular bone volume density; Tb.N, trabecular number; Tb.Th, trabecular thickness; and Conn.D, connectivity density.