Comparison of clinical and cytogenetic data in CD5− versus CD5+ SMZL cases
| Characteristic . | CD5−, N (median or %) . | CD5+, N (median or %) . | P . |
|---|---|---|---|
| Age, y, ≥ 65 y | (68) | (67) | .898 |
| Sex, male/female | 0.85 | 1.05 | .712 |
| Hemoglobin, g/dL, ≤ 12 g/dL | (11) | (11) | .959 |
| β2-Microglobulin, > 3 mg/L | 31/50 (62%) | 16/24 (66.6%) | .696 |
| LDH, > 450 mg/L | 15/62 (24%) | 10/24 (41%) | .109 |
| WBCs, ×109/L, ≥ 10 × 109/L | 100 (12 300) | 32 (13 165) | .316 |
| Lymphocytes, ×109/L, ≥ 5 × 109/L | 95 (5300) | 33 (6900) | .454 |
| Villous lymphocytes | 27/37 (73%) | 12/18 (66.6%) | .629 |
| IGHV mutated | 30/50 (60%) | 9/14 (64%) | .771 |
| Median survival time, y | 9.4 | 10.6 | .898 |
| Cytogenetic findings | |||
| +3/+3q*† | 29/119 (24%) | 16/39 (41%) | .004§ |
| del(7q) | 47/119 (39.5%) | 13/39 (33%) | .491 |
| +12 | 7/119 (6%) | 3/39 (7.7%) | .709 |
| 14q32 | 9/119 (7%) | 3/39 (7%) | 1.000 |
| del TP53 | 11/55 (20%) | 6/20 (30%) | .367 |
| +18† | 8/119 (7%) | 7/39 (18%) | .038§ |
| 6q† | 7/119 (6%) | 9/39 (23%) | .004§ |
| Abnormal karyotype | 90/119 (75.6%) | 32/38 (84.2%) | .269 |
| Single anomaly‡ | 28/90 (31%) | 4/32 (12.5%) | .040§ |
| More than or equal to 3 alterations | 46/90 (51%) | 18/32 (56.3%) | .073 |
| Characteristic . | CD5−, N (median or %) . | CD5+, N (median or %) . | P . |
|---|---|---|---|
| Age, y, ≥ 65 y | (68) | (67) | .898 |
| Sex, male/female | 0.85 | 1.05 | .712 |
| Hemoglobin, g/dL, ≤ 12 g/dL | (11) | (11) | .959 |
| β2-Microglobulin, > 3 mg/L | 31/50 (62%) | 16/24 (66.6%) | .696 |
| LDH, > 450 mg/L | 15/62 (24%) | 10/24 (41%) | .109 |
| WBCs, ×109/L, ≥ 10 × 109/L | 100 (12 300) | 32 (13 165) | .316 |
| Lymphocytes, ×109/L, ≥ 5 × 109/L | 95 (5300) | 33 (6900) | .454 |
| Villous lymphocytes | 27/37 (73%) | 12/18 (66.6%) | .629 |
| IGHV mutated | 30/50 (60%) | 9/14 (64%) | .771 |
| Median survival time, y | 9.4 | 10.6 | .898 |
| Cytogenetic findings | |||
| +3/+3q*† | 29/119 (24%) | 16/39 (41%) | .004§ |
| del(7q) | 47/119 (39.5%) | 13/39 (33%) | .491 |
| +12 | 7/119 (6%) | 3/39 (7.7%) | .709 |
| 14q32 | 9/119 (7%) | 3/39 (7%) | 1.000 |
| del TP53 | 11/55 (20%) | 6/20 (30%) | .367 |
| +18† | 8/119 (7%) | 7/39 (18%) | .038§ |
| 6q† | 7/119 (6%) | 9/39 (23%) | .004§ |
| Abnormal karyotype | 90/119 (75.6%) | 32/38 (84.2%) | .269 |
| Single anomaly‡ | 28/90 (31%) | 4/32 (12.5%) | .040§ |
| More than or equal to 3 alterations | 46/90 (51%) | 18/32 (56.3%) | .073 |