Table 6 Summary of murine DCB... | American Society of Hematology

Table 6

Summary of murine DCB transplantation results and correlation with clinical engraftment

Infused cell type	N	Single-unit dominance	Correlation of murine engraftment with clinically engrafting unit
DCB MNCs	21	18 of 21 (86%)	18 of 21 (86%)
DCB CD34⁺	11	1 of 11 (9%) in 2 of 3 mice	1 of 11 (9%) in 2 of 3 mice
DCB CD34⁺ + add-back CD34⁻ from clinically	9	9 of 9 (100%) in BM or spleen or both	9 of 9 (100%) clinically engrafting unit (CD34⁻ origin)
engrafting unit	9	9 of 9 (100%) in BM or spleen or both	9 of 9 (100%) clinically engrafting unit (CD34⁻ origin)
DCB CD34⁺ + add-back CD34⁻ from clinically nonengrafting unit	11	9 of 11 (82%) in BM or SP or both, with remaining 2 predominantly nonengrafting unit	0 of 11 (0%) clinically engrafting unit; 11 of 11 (100%) engrafted predominantly or exclusively with clinically nonengrafting unit (CD34⁻ origin)

Infused cell type	N	Single-unit dominance	Correlation of murine engraftment with clinically engrafting unit
DCB MNCs	21	18 of 21 (86%)	18 of 21 (86%)
DCB CD34⁺	11	1 of 11 (9%) in 2 of 3 mice	1 of 11 (9%) in 2 of 3 mice
DCB CD34⁺ + add-back CD34⁻ from clinically	9	9 of 9 (100%) in BM or spleen or both	9 of 9 (100%) clinically engrafting unit (CD34⁻ origin)
engrafting unit	9	9 of 9 (100%) in BM or spleen or both	9 of 9 (100%) clinically engrafting unit (CD34⁻ origin)
DCB CD34⁺ + add-back CD34⁻ from clinically nonengrafting unit	11	9 of 11 (82%) in BM or SP or both, with remaining 2 predominantly nonengrafting unit	0 of 11 (0%) clinically engrafting unit; 11 of 11 (100%) engrafted predominantly or exclusively with clinically nonengrafting unit (CD34⁻ origin)