Table 4

Percentage engraftment of clinically engrafting unit after murine MNC DCB transplantation (n = 12) and correlation with patient engraftment: MNC DCB transplantation shows unit dominance and clinical correlation

Experiment no.Clinically engrafting unit in murine BM, %Clinically engrafting unit in murine spleen, %Clinically engrafting unit in patient, %
1 100 100 100 
2 100 100 100 
3 100 100 100 
4 100 100 100 
5 100 100 100 
6 100 100 100 
7 100 100 100 
8 83 unit 1* (17 unit 2) 91 unit 1* (9 unit 2) 61 unit 1, 39 unit 2* (3 y: 69 unit 1, 31 unit 2) 
9 100 100 100 
10 100 100 100 
11 100 Inadequate 100 
12 0 (100)† Inadequate 100 
Experiment no.Clinically engrafting unit in murine BM, %Clinically engrafting unit in murine spleen, %Clinically engrafting unit in patient, %
1 100 100 100 
2 100 100 100 
3 100 100 100 
4 100 100 100 
5 100 100 100 
6 100 100 100 
7 100 100 100 
8 83 unit 1* (17 unit 2) 91 unit 1* (9 unit 2) 61 unit 1, 39 unit 2* (3 y: 69 unit 1, 31 unit 2) 
9 100 100 100 
10 100 100 100 
11 100 Inadequate 100 
12 0 (100)† Inadequate 100 

Inadequate indicates that the DNA sample was inadequate to quantify engraftment of each unit.

*

The mice had coengraftment of both units, and the patient had sustained coengraftment of both units for more than 3 years to date. Unit 1 was the predominating unit, but there was also sustained coengraftment of unit 2.

†

As indicated in parentheses, mice engrafted with the clinically nonengrafting unit.

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