Table 3

Results of NSG murine transplantations using MNCs (n = 12): high levels of human engraftment were observed with the clinically engrafting unit transplanted alone, the clinically nonengrafting unit transplanted alone, and with DCB combination

Experiment no.Mean human CD45+ percentage engraftment
Clinically engrafting unit alone
Clinically nonengrafting unit alone
DCB transplantation
BMSpleenBMSpleenBMSpleen
31 34 27 33 24 30 
12 12 10 16 
12 15 
21 29 17 24 20 26 
33 52 20 32 31 45 
11 14 15 25 
25 44 46 57 45 72 
22 53 48 78 27 22 
88 74 68 70 38 82 
10 44 87 53 52 25 
11 Pre Pre 13 15 
12 15 14 
Experiment no.Mean human CD45+ percentage engraftment
Clinically engrafting unit alone
Clinically nonengrafting unit alone
DCB transplantation
BMSpleenBMSpleenBMSpleen
31 34 27 33 24 30 
12 12 10 16 
12 15 
21 29 17 24 20 26 
33 52 20 32 31 45 
11 14 15 25 
25 44 46 57 45 72 
22 53 48 78 27 22 
88 74 68 70 38 82 
10 44 87 53 52 25 
11 Pre Pre 13 15 
12 15 14 

Mice were killed at a median of 6 weeks after transplantation.

Pre indicates premature mice mortality.