Multivariate analysis (Cox regression) for the OS in all patients, patients without APL, and patients with intermediate cytogenetics
| Variable . | HR . | OS . | P . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lower 95% CI . | Upper 95% CI . | |||||||||||
| All . | non-APL . | Int . | All . | non-APL . | Int . | All . | non-APL . | Int . | All . | non-APL . | Int . | |
| Age > 50 y | 2.668 | 2.954 | 2.533 | 1.857 | 2.024 | 1.616 | 3.832 | 4.311 | 3.971 | < .001 | < .001 | < .001 |
| Unfavorable karyotype | 2.762 | 2.544 | NA | 1.661 | 1.529 | NA | 4.587 | 4.237 | NA | < .001 | < .001 | NA |
| NPM1+/FLT3-ITD− | 0.348 | 0.300 | 0.310 | 0.159 | 0.137 | 0.139 | 0.762 | 0.658 | 0.694 | .008 | .003 | .004 |
| CEBPAdouble mutation | 0.364 | 0.305 | 0.250 | 0.159 | 0.133 | 0.107 | 0.831 | 0.701 | 0.583 | .017 | .005 | .001 |
| RUNX1 mutation | 1.848 | 1.727 | 1.420 | 1.039 | 0.975 | 0.766 | 3.289 | 3.058 | 2.638 | .036 | .061 | .264 |
| WT1 mutation | 2.403 | 2.028 | 2.061 | 1.326 | 1.094 | 1.044 | 4.347 | 3.759 | 4.065 | .004 | .025 | .037 |
| ASXL1 mutation | 1.472 | 1.326 | 1.479 | 0.807 | 0.732 | 0.733 | 2.688 | 2.403 | 2.985 | .207 | .352 | .274 |
| Variable . | HR . | OS . | P . | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lower 95% CI . | Upper 95% CI . | |||||||||||
| All . | non-APL . | Int . | All . | non-APL . | Int . | All . | non-APL . | Int . | All . | non-APL . | Int . | |
| Age > 50 y | 2.668 | 2.954 | 2.533 | 1.857 | 2.024 | 1.616 | 3.832 | 4.311 | 3.971 | < .001 | < .001 | < .001 |
| Unfavorable karyotype | 2.762 | 2.544 | NA | 1.661 | 1.529 | NA | 4.587 | 4.237 | NA | < .001 | < .001 | NA |
| NPM1+/FLT3-ITD− | 0.348 | 0.300 | 0.310 | 0.159 | 0.137 | 0.139 | 0.762 | 0.658 | 0.694 | .008 | .003 | .004 |
| CEBPAdouble mutation | 0.364 | 0.305 | 0.250 | 0.159 | 0.133 | 0.107 | 0.831 | 0.701 | 0.583 | .017 | .005 | .001 |
| RUNX1 mutation | 1.848 | 1.727 | 1.420 | 1.039 | 0.975 | 0.766 | 3.289 | 3.058 | 2.638 | .036 | .061 | .264 |
| WT1 mutation | 2.403 | 2.028 | 2.061 | 1.326 | 1.094 | 1.044 | 4.347 | 3.759 | 4.065 | .004 | .025 | .037 |
| ASXL1 mutation | 1.472 | 1.326 | 1.479 | 0.807 | 0.732 | 0.733 | 2.688 | 2.403 | 2.985 | .207 | .352 | .274 |
OS indicates overall survival; APL, acute promyelocytic leukemia; HR, hazard ratio; Int, intermediate cytogenetics; NA, not applicable; and ITD, internal tandem duplication.